IMPA2 - inositol monophosphatase 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3613

About IMPA2

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:11,981,507-12,030,877 (from NCBI)

This gene has 12 transcripts (splice variants), 158 orthologues and 4 paralogues. Broad expression in kidney (RPKM 73.3), skin (RPKM 38.8) and 18 other tissues.

Summary

This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]

IMPA2 Products (1)

mRNA Protein Name
NM_014214.3 NP_055029.1 inositol monophosphatase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables inositol monophosphate 1-phosphatase activity IDA
IDA: Inferred from direct assay
17068342 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
17068342 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in response to lithium ion IDA
IDA: Inferred from direct assay
15504365 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17068342 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IMPA2 Protein Structure

Inositol_P

Inositol_P: Inositol monophosphatase family (17 - 280)

  • 0
  • 100
  • 200
  • 288 a.a.
Protein Preferred Names Protein Names

inositol monophosphatase 2

  • IMP 2

IMPA2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
IMPA2 O14732 SLC44A3 Homo sapiens Q8N4M1-3
Validated Y2H
32296183
Intra
IMPA2 O14732 IMPA1 Homo sapiens P29218-3
Y2H Prey Pooling
32296183
Intra
IMPA2 O14732 IMPA1 Homo sapiens P29218-3
Validated Y2H
32296183
Intra
IMPA2 O14732 IMPA1 Homo sapiens P29218-3
Y2H Array
32296183
Intra
IMPA2 O14732 UBA3 Homo sapiens Q8TBC4
Y2H Prey Pooling
32296183
Intra
IMPA2 O14732 UBA3 Homo sapiens Q8TBC4
Validated Y2H
25416956
Intra
IMPA2 O14732 UBA3 Homo sapiens Q8TBC4
Validated Y2H
32296183
Intra
IMPA2 O14732 UBA3 Homo sapiens Q8TBC4
Y2H Array
32296183
Intra
IMPA2 O14732 IMPA1 Homo sapiens P29218
Y2H Prey Pooling
25416956
Intra
IMPA2 O14732 IMPA1 Homo sapiens P29218
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IMPA2 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70197 IMPA2 Protein, Human (His) O14732-1 (M1-K288) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Febrile Seizures

  • Febrile Seizure

  • Febrile Convulsions

  • Seizures Febrile
Mood Disorder

  • Mood Disorders

  • Episodic Mood Disorder
Ring Dermoid Of Cornea

  • RDC

  • Ring Dermoid Syndrome

  • Bilateral, Annular Limbal Dermoids With Corneal And Conjunctival Extension

  • Dermoid Of Cornea, Ring
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Familial Febrile Seizures

  • Familial Febrile Convulsions

  • Feb

  • Febrile Seizures, Familial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06796 IMPA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20427 Impa2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26936 Impa2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IMPA2 RGD RGD:628692
Canis familiaris IMPA2 VGNC VGNC:49913
Mus musculus IMPA2 MGD MGI:2149728
Bos taurus IMPA2 VGNC VGNC:30185
Others IMPA2 NCBI