ARL3 - ADP ribosylation factor like GTPase 3 Gene

Also Known as RP83; ARFL3; JBTS35

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 403

About ARL3

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,673,731-102,714,397 (from NCBI)

This gene has 1 transcript (splice variant), 274 orthologues, 30 paralogues and is associated with 6 phenotypes. Ubiquitous expression in brain (RPKM 13.2), kidney (RPKM 7.9) and 24 other tissues.

Summary

ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity. [provided by RefSeq, Jul 2008]

ARL3 Products (1)

mRNA	Protein	Name
NM_004311.4	NP_004302.1	ADP-ribosylation factor-like protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables GDP binding	IDA IDA: Inferred from direct assay	18588884	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	18588884	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	12417528	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11847227	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	22085962	GOA
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	16525022	GOA
acts upstream of or within post-Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	20106869	GOA
involved in protein localization to cilium	IMP IMP: Inferred from mutant phenotype	30269812	GOA
involved in small GTPase-mediated signal transduction	IDA IDA: Inferred from direct assay	22085962	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	16525022	GOA
located in centrosome	IDA IDA: Inferred from direct assay	16525022	GOA
NOT located in cilium	IDA IDA: Inferred from direct assay	17646400	GOA
located in cilium	IDA IDA: Inferred from direct assay	16525022	GOA
located in cytoplasmic microtubule	IDA IDA: Inferred from direct assay	12417528	GOA
located in midbody	IDA IDA: Inferred from direct assay	16525022	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16525022	GOA
located in photoreceptor connecting cilium	IDA IDA: Inferred from direct assay	12417528	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	16525022	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL3 Protein Structure

Arf

0
100
182 a.a.

Protein Preferred Names	Protein Names
ADP-ribosylation factor-like protein 3	ADP-ribosylation factor-like 3

ARL3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ARL3	P36405	ARL2BP	Homo sapiens	Q9Y2Y0	TAP	26455799
Intra	ARL3	P36405	ARL2BP	Homo sapiens	Q9Y2Y0	TAP	27173435
Intra	ARL3	P36405	ARL2BP	Homo sapiens	Q9Y2Y0	Validated Y2H	32296183
Intra	ARL3	P36405	UNC119	Homo sapiens	Q13432	Y2H Pooling	16169070
Intra	ARL3	P36405	UNC119	Homo sapiens	Q13432	TAP	27173435
Intra	ARL3	P36405	UNC119	Homo sapiens	Q13432	Validated Y2H	32296183
Intra	ARL3	P36405	UNC119	Homo sapiens	Q13432	TAP	26455799
Intra	ARL3	P36405	UNC119	Homo sapiens	Q13432	FPS	18588884
Intra	ARL3	P36405	UNC119	Homo sapiens	Q13432	GMS	18588884
Intra	ARL3	P36405	PDE6D	Homo sapiens	O43924	TAP	26455799
Intra	ARL3	P36405	PDE6D	Homo sapiens	O43924	Y2H Pooling	16169070
Intra	ARL3	P36405	PDE6D	Homo sapiens	O43924	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Joubert Syndrome 35	JBTS35 Joubert Syndrome, Type 35
Retinitis Pigmentosa 83	RP83 Retinitis Pigmentosa, Type 83
Progressive Cone Dystrophy	Cone Dystrophy Cone Dystrophy Progressive
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa 2	RP2 X-Linked Retinitis Pigmentosa 2 Xlrp2 Xlrp-2 Retinitis Pigmentosa-2 Retinitis Pigmentosa, Type 2
Joubert Syndrome 22	JBTS22 Joubert Syndrome, Type 22
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Renal-Hepatic-Pancreatic Dysplasia	Ivemark'S Syndrome Ivemark Ii Syndrome Renohepaticopancreatic Dysplasia
Nephronophthisis 2	NPHP2 Nph2 Nephronophthisis 2, Infantile Infantile Nephronophthisis 2 Infantile Nephronophthisis Nephronophthisis, Type 2
Cone-Rod Dystrophy 16	Retinitis Pigmentosa 64 Retinal Dystrophy With Early Macular Involvement CORD16 RP64
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary
Cone Dystrophy	Retinal Cone Dystrophy Dystrophy, Cone Cone Dystrophy 3
Meckel Syndrome, Type 1	Meckel-Gruber Syndrome Meckel Syndrome Dysencephalia Splanchnocystica Meckel Syndrome 1 MKS1 Mks Gruber Syndrome Meckel-Gruber Syndrome, Type 1 Mes Dysencephalia Splachnocystica Meckel Gruber Syndrome Meckel Syndrome Type 1
Visceral Heterotaxy	Situs Ambiguus Heterotaxia Heterotaxy Syndrome Heterotaxy Lateralization Defect Situs Ambiguous Left Isomerism Htx Ivemark Syndrome Right Isomerism Situs Ambiguus Viscerum Incomplete Situs Inversus Partial Situs Inversus Heterotaxy, Visceral Asplenia Syndrome Bilateral Left-Sidedness Polysplenia Syndrome Moller Syndrome
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS00987	ARL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ARL3	MGD	MGI:1929699
Canis familiaris	ARL3	VGNC	VGNC:38111
Bos taurus	ARL3	VGNC	VGNC:26143
Felis catus	ARL3	VGNC	VGNC:68209
Rattus norvegicus	ARL3	RGD	RGD:69327
Others	ARL3	NCBI