NARS1 - asparaginyl-tRNA synthetase 1 Gene

Also Known as NARS; ASNRS; NEDMILG; NEDMILEG

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4677

About NARS1

Cytogenetic location: 18q21.31 Genomic coordinates (GRCh38): 18:57,600,656-57,621,836 (from NCBI)

This gene has 12 transcripts (splice variants), 233 orthologues, 4 paralogues and is associated with 4 phenotypes. Ubiquitous expression in thyroid (RPKM 64.3), kidney (RPKM 57.0) and 25 other tissues.

Summary

Aminoacyl-tRNA synthetases are a class of Enzymes that charge tRNAs with their cognate Amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

NARS1 Products (1)

mRNA	Protein	Name
NM_004539.4	NP_004530.1	asparagine--tRNA ligase, cytoplasmic

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables CCR3 chemokine receptor binding	IDA IDA: Inferred from direct assay	30171954	GOA
enables asparagine-tRNA ligase activity	IMP IMP: Inferred from mutant phenotype	9421509	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA
enables protein dimerization activity	IDA IDA: Inferred from direct assay	9421509	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in asparaginyl-tRNA aminoacylation	IDA IDA: Inferred from direct assay	9421509	GOA
involved in cell migration	IDA IDA: Inferred from direct assay	9421509	GOA
involved in cerebral cortex development	IMP IMP: Inferred from mutant phenotype	32788587	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NARS1 Protein Structure

tRNA_anti-codon

tRNA-synt_2

0
100
200
300
400
500
548 a.a.

Protein Preferred Names	Protein Names
asparagine--tRNA ligase, cytoplasmic	asparagine tRNA ligase 1, cytoplasmic

NARS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	NARS1	O43776	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	NARS1	O43776	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	NARS1	O43776	ATXN1	Homo sapiens	P54253	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NARS1 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P74738	NARS Protein, Human (sf9, His)	O43776 (M1-P548)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Neurodevelopmental Disorder With Microcephaly, Impaired Language, Epilepsy, And Gait Abnormalities	NEDMILEG Neurodevelopmental Disorder With Microcephaly, Impaired Language, Epilepsy, And Gait Abnormalities, Autosomal Dominant
Neurodevelopmental Disorder With Microcephaly, Impaired Language, And Gait Abnormalities	NEDMILG Neurodevelopmental Disorder With Microcephaly, Impaired Language, And Gait Abnormalities, Autosomal Recessive
Mitochondrial Complex I Deficiency, Nuclear Type 35	MC1DN35 Mitochondrial Complex 1 Deficiency, Nuclear Type 35 Nuclear Type Mitochondrial Complex I Deficiency 35
Myositis	Idiopathic Inflammatory Myopathy Idiopathic Inflammatory Myositis Iim Imm Idiopathic Inflammatory Myopathies Myopathy, Familial Idiopathic Inflammatory Inflammatory Disorder Of Muscle Idiopathic Inflammatory Myopathy, Familial Inflammatory Myopathy, Idiopathic Myopathies Idiopathic Inflammatory Familial Idiopathic Inflammatory Myopathy
Interstitial Lung Disease	Ild Lung Diseases, Interstitial Lung Diseases Interstitial Interstitial Lung Diseases
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Deafness, Autosomal Recessive 94	DFNB94 Autosomal Recessive Nonsyndromic Deafness 94 Autosomal Recessive Deafness 94 Deafness, Autosomal Recessive, 94
Filarial Elephantiasis	Lymphatic Filariasis Elephantiasis Filariasis Bancroftian Elephantiasis Bancroftian Filarial Chyluria Elephantiasis Of Eyelid Bancroftian Filariasis Elephantitis Malayi Tropical Eosinphilia Wuchereria Bancrofti Infection Wuchereriasis Elephantiasis, Filarial Filarial Elephantiases Infection By Wuchereria Bancrofti Filarial Lymphangitis Tropical Elephantiasis Filarial Chylocele
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P2996B	Nitrate Reductase (NAD[P]H), Pichia Pastoris (recombinant)		/	Unkown
HY-RS09036	NARS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22670	Nars1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29184	Nars1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NARS1	RGD	RGD:1307238
Mus musculus	NARS1	MGD	MGI:1917473
Felis catus	NARS1	VGNC	VGNC:68416
Macaca mulatta	NARS1	VGNC	VGNC:75132
Canis familiaris	NARS1	VGNC	VGNC:43625
Others	NARS1	NCBI