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NFYA - nuclear transcription factor Y subunit alpha Gene

Also Known as HAP2; CBF-A; CBF-B; NF-YA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4800

About NFYA

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,072,974-41,102,403 (from NCBI)

This gene has 2 transcripts (splice variants) and 234 orthologues. Ubiquitous expression in testis (RPKM 5.4), brain (RPKM 3.2) and 25 other tissues.

Summary

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]

NFYA Products (2)

mRNA	Protein	Name
NM_002505.5	NP_002496.1	nuclear transcription factor Y subunit alpha isoform 1
NM_021705.4	NP_068351.1	nuclear transcription factor Y subunit alpha isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15243141	GOA
contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11256944	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10571058	GOA
contributes to transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	11256944	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23332751	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15243141	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of CCAAT-binding factor complex	IDA IDA: Inferred from direct assay	15243141	GOA
part of CCAAT-binding factor complex	IPI IPI: Inferred from physical interaction	23332751	GOA
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	11256944	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15243141	GOA
part of protein-DNA complex	IDA IDA: Inferred from direct assay	11256944	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFYA Protein Structure

CBFB_NFYA

0
100
200
300
347 a.a.

Protein Preferred Names	Protein Names
nuclear transcription factor Y subunit alpha	CAAT-box DNA binding protein subunit A

NFYA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	NFYA	P23511	POGZ	Homo sapiens	Q7Z3K3	Y2H Array	25416956
Intra	NFYA	P23511	CSNK2A1	Homo sapiens	P68400	Y2H Array	25416956
Intra	NFYA	P23511	CSNK2A1	Homo sapiens	P68400	Validated Y2H	25416956
Intra	NFYA	P23511	CSNK2A1	Homo sapiens	P68400	Y2H Array	29892012
Intra	NFYA	P23511	LUC7L2	Homo sapiens	Q9Y383	Validated Y2H	25416956
Intra	NFYA	P23511	LUC7L2	Homo sapiens	Q9Y383	Y2H Array	31515488
Intra	NFYA	P23511	LUC7L2	Homo sapiens	Q9Y383	Y2H Array	25416956
Intra	NFYA	P23511	TP53	Homo sapiens	P04637	Imaging	16959611
Intra	NFYA	P23511	TP53	Homo sapiens	P04637	Anti Bait CoIP	16959611
Intra	NFYA	P23511	GTF2A1	Homo sapiens	P52655	Y2H Array	25416956
Intra	NFYA	P23511	NFYB	Homo sapiens	P25208	Y2H Prey Pooling	25416956
Intra	NFYA	P23511	NFYB	Homo sapiens	P25208	Validated Y2H	25416956
Intra	NFYA	P23511	NFYB	Homo sapiens	P25208	X-Ray Diffraction	23332751
Intra	NFYA	P23511	NFYB	Homo sapiens	P25208	Biochemical	15243141
Intra	NFYA	P23511	NFYB	Homo sapiens	P25208	Anti Bait CoIP	16959611
Intra	NFYA	P23511	NFYB	Homo sapiens	P25208	CoIP	15243141
Intra	NFYA	P23511	NFYC	Homo sapiens	Q13952	X-Ray Diffraction	23332751
Intra	NFYA	P23511	NFYC	Homo sapiens	Q13952	CoIP	15243141
Intra	NFYA	P23511	NFYC	Homo sapiens	Q13952	Biochemical	15243141
Intra	NFYA	P23511	NFYC	Homo sapiens	Q13952	Anti Tag CoIP	33961781
Intra	NFYA	P23511	SRSF1	Homo sapiens	Q07955	Imaging	15243141
Intra	NFYA	P23511	SRSF1	Homo sapiens	Q07955	Biochemical	15243141
Intra	NFYA	P23511	SRSF1	Homo sapiens	Q07955	CoIP	15243141
Intra	NFYA	P23511	APPBP2	Homo sapiens	Q92624	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NFYA Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P71135	NFYA Protein, Human	P23511-2 (M1-S318)	≥ 95%, as determined by reducing SDS-PAGE.

NFYA Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81651	NFYA Antibody (YA1396)	WB, IP	Human, Mouse, Rat
HY-P81651A	NFYA Antibody (YA1396)(PBS only)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Adult Acute Monocytic Leukemia	Adult Acute Monoblastic And Acute Monocytic Leukemia
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-128020	ML114	Inhibitor	/	Unkown
HY-182392	NFYi5		/	Unkown
HY-RS09271	NFYA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20307	Nfya Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26815	Nfya Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NFYA	MGD	MGI:97316
Canis familiaris	NFYA	VGNC	VGNC:43790
Rattus norvegicus	NFYA	RGD	RGD:70976
Macaca mulatta	NFYA	VGNC	VGNC:75344
Felis catus	NFYA	VGNC	VGNC:68491
Bos taurus	NFYA	VGNC	VGNC:32055
Others	NFYA	NCBI