2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. ML114

ML114 is a specific inhibitor of RBBP9 serine hydrolase, with an IC50 of 0.63 μM against recombinant RBBP9. ML114 can inhibit the proliferation of human pluripotent stem cells (hPSCs) by regulating the expression of NFYA and other factors, but does not induce differentiation. ML114 can be used in the research of diseases such as retinoblastoma.

For research use only. We do not sell to patients.

ML114

ML114 Chemical Structure

CAS No. : 866149-26-0

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Description

ML114 is a specific inhibitor of RBBP9 serine hydrolase, with an IC50 of 0.63 μM against recombinant RBBP9. ML114 can inhibit the proliferation of human pluripotent stem cells (hPSCs) by regulating the expression of NFYA and other factors, but does not induce differentiation. ML114 can be used in the research of diseases such as retinoblastoma[1].

Cellular Effect
Cell Line Type Value Description References
HEK-293T IC50
0.64 μM
Compound: 18
Displacement of fluorophosphate-rhodamine from RBBP9 transfected in human HEK293T cells proteomes after 30 mins by SDS-PAGE gel fluorescence assay
Displacement of fluorophosphate-rhodamine from RBBP9 transfected in human HEK293T cells proteomes after 30 mins by SDS-PAGE gel fluorescence assay
[PMID: 20207142]
Molecular Weight

252.33

Formula

C12H16N2O2S
CAS No.
SMILES

C/C(C1=NC=CS1)=N\OC(C2CCCCC2)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ML114 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML114866149-26-0ML 114ML-114PhospholipaseRBBP9serine hydrolasehPSCsretinoblastomaInhibitorinhibitorinhibit

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