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APBB1IP - amyloid beta precursor protein binding family B member 1 interacting protein Gene

Also Known as RIAM; INAG1; PREL1; RARP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54518

About APBB1IP

Cytogenetic location: 10p12.1 Genomic coordinates (GRCh38): 10:26,438,341-26,567,803 (from NCBI)

This gene has 3 transcripts (splice variants), 257 orthologues and 4 paralogues. Broad expression in appendix (RPKM 24.2), spleen (RPKM 22.5) and 16 other tissues.

Summary

Predicted to be involved in signal transduction. Predicted to act upstream of or within T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell and positive regulation of cell adhesion. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

APBB1IP Products (1)

mRNA	Protein	Name
NM_019043.4	NP_061916.3	amyloid beta A4 precursor protein-binding family B member 1-interacting protein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22084112	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APBB1IP Protein Structure

0
200
400
600
666 a.a.

Protein Preferred Names	Protein Names
amyloid beta A4 precursor protein-binding family B member 1-interacting protein	APBB1-interacting protein 1

APBB1IP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	APBB1IP	Q7Z5R6	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
Intra	APBB1IP	Q7Z5R6	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Leukocyte Adhesion Deficiency, Type I	Leukocyte Adhesion Deficiency Leukocyte Adhesion Deficiency 1 LAD1 Lad Lymphocyte Function-Associated Antigen 1 Immunodeficiency Leukocyte Adhesion Deficiency Type I Leukocyte Adhesion Deficiency Type 1 Linear Iga Bullous Dermatosis Linear Iga Dermatosis Leukocyte-Adhesion Deficiency Syndrome Lfa1 Immunodeficiency Congenital Leukocyte Adherence Deficiency Lad-I Linear Iga Disease Leukocyte Adhesion Deficiency Syndrome Lad 1 Lfa 1 Immunodeficiency Linear Immunoglobulin A Dermatosis Leucocyte Adhesion Deficiency Type 1 Leukocyte Adhesion Molecule Deficiency Type 1
Leukocyte Adhesion Deficiency, Type Iii	Leukocyte Adhesion Deficiency 3 LAD3 Leukocyte Adhesion Deficiency 1 Variant Lad1v Integrin Activation Deficiency Disease Iadd Leukocyte Adhesion Deficiency Type Iii Lad1 Variant Lad-1 Variant Lad-Iii Leukocyte Adhesion Deficiency-1 Variant Leukocyte Adhesion Deficiency Type 1
Rocky Mountain Spotted Fever	Brazillian Spotted Choix Exanthematic Typhus Of Sao Paulo Fiebre Maculosa Fiebre Manchada Sao Paulo Typhus So Paulo Fever Tick Typhus Tobia Fever Rmsf Typhus, Tick
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS00805	APBB1IP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	APBB1IP	VGNC	VGNC:100295
Canis familiaris	APBB1IP	VGNC	VGNC:37978
Rattus norvegicus	APBB1IP	RGD	RGD:1304795
Felis catus	APBB1IP	VGNC	VGNC:59844
Bos taurus	APBB1IP	VGNC	VGNC:26004
Mus musculus	APBB1IP	MGD	MGI:1861354