AURKAIP1 - aurora kinase A interacting protein 1 Gene

Also Known as AIP; AKIP; MRP-S38

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54998

About AURKAIP1

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,373,736-1,375,207 (from NCBI)

This gene has 6 transcripts (splice variants) and 189 orthologues. Ubiquitous expression in testis (RPKM 40.0), kidney (RPKM 27.3) and 25 other tissues.

Summary

Acts upstream of or within positive regulation of proteolysis. Located in mitochondrion and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

AURKAIP1 Products (3)

mRNA Protein Name
NM_001127229.2 NP_001120701.1 aurora kinase A-interacting protein
NM_001127230.2 NP_001120702.1 aurora kinase A-interacting protein
NM_017900.3 NP_060370.1 aurora kinase A-interacting protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
12244051 GOA
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within positive regulation of proteolysis IDA
IDA: Inferred from direct assay
12244051 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
27184847 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12244051 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AURKAIP1 Protein Structure

DUF1713

DUF1713: Mitochondrial domain of unknown function (DUF1713) (126 - 158)

  • 0
  • 100
  • 199 a.a.
Protein Preferred Names Protein Names

aurora kinase A-interacting protein

  • 28S ribosomal protein S38, mitochondrial

AURKAIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
AURKAIP1 Q9NWT8 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra
AURKAIP1 Q9NWT8 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra
AURKAIP1 Q9NWT8 AURKA Homo sapiens O14965
Anti Bait CoIP
12244051
Intra
AURKAIP1 Q9NWT8 AURKA Homo sapiens O14965
Anti Tag CoIP
12244051
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hermansky-Pudlak Syndrome 3

  • HPS3

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

  • Delta Storage Pool Disease

  • Hermansky-Pudlak Syndrome, Type 3

  • Platelet Storage Pool Deficiency

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS01269 AURKAIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris AURKAIP1 VGNC VGNC:56004
Macaca mulatta AURKAIP1 VGNC VGNC:106321
Bos taurus AURKAIP1 VGNC VGNC:26350
Mus musculus AURKAIP1 MGD MGI:1913327
Felis catus AURKAIP1 VGNC VGNC:60043
Others AURKAIP1 NCBI