VSNL1 - visinin like 1 Gene
Also Known as HLP3; VILIP; HPCAL3; HUVISL1; VILIP-1
Species: Homo sapiens
About VSNL1
This gene has 6 transcripts (splice variants), 263 orthologues and 14 paralogues. Biased expression in brain (RPKM 206.9), esophagus (RPKM 16.5) and 2 other tissues.
Summary
This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
VSNL1 Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_001366803.2 | NP_001353732.1 | visinin-like protein 1 isoform 1 |
| NM_001366804.2 | NP_001353733.1 | visinin-like protein 1 isoform 2 |
| NM_001366805.2 | NP_001353734.1 | visinin-like protein 1 isoform 3 |
| NM_001366806.2 | NP_001353735.1 | visinin-like protein 1 isoform 1 |
| NM_003385.5 | NP_003376.2 | visinin-like protein 1 isoform 1 |
| Molecular Function GO Annotation | Evidence | Verweise | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
VSNL1 Protein Structure
EF-hand_1: EF hand (66 - 90)
EF-hand_7: EF-hand domain pair (101 - 174)
- 0
- 100
- 191 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
visinin-like protein 1 |
|
VSNL1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Verweise |
|---|---|---|---|---|---|---|---|
|
Intra
|
VSNL1 | P62760 | TEX13B | Homo sapiens | Q9BXU2 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | TEX13B | Homo sapiens | Q9BXU2 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | TEX13B | Homo sapiens | Q9BXU2 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | SPRY3 | Homo sapiens | O43610 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | SPRY3 | Homo sapiens | O43610 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | SRL | Homo sapiens | Q86TD4-2 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | a0a1u9x8x8_human | Homo sapiens | A0A1U9X8X8 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | a0a1u9x8x8_human | Homo sapiens | A0A1U9X8X8 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | COL10A1 | Homo sapiens | Q03692 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | C1QTNF2 | Homo sapiens | Q9BXJ5 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | C1QTNF2 | Homo sapiens | Q9BXJ5 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | C1QTNF2 | Homo sapiens | Q9BXJ5 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | SPRED1 | Homo sapiens | Q7Z699 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | SPRED1 | Homo sapiens | Q7Z699 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | SPRED1 | Homo sapiens | Q7Z699 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | SPRED2 | Homo sapiens | Q7Z698 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | LITAF | Homo sapiens | Q99732 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | DTX2 | Homo sapiens | Q86UW9 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | DTX2 | Homo sapiens | Q86UW9 | 25416956 | |
|
Intra
|
VSNL1 | P62760 | DTX2 | Homo sapiens | Q86UW9 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | DTX2 | Homo sapiens | Q86UW9 | 25416956 | |
|
Intra
|
VSNL1 | P62760 | DTX2 | Homo sapiens | Q86UW9 | 16189514 | |
|
Intra
|
VSNL1 | P62760 | DTX2 | Homo sapiens | Q86UW9 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | FAM131C | Homo sapiens | Q96AQ9 | 16189514 | |
|
Intra
|
VSNL1 | P62760 | FAM131C | Homo sapiens | Q96AQ9 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | FAM131C | Homo sapiens | Q96AQ9 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | FAM131C | Homo sapiens | Q96AQ9 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | TFF1 | Homo sapiens | P04155 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | TFF1 | Homo sapiens | P04155 | 32296183 | |
|
Intra
|
VSNL1 | P62760 | ATXN1 | Homo sapiens | P54253 | 16713569 |
Recombinant VSNL1 Proteins
| Art. -Nr. | Produktname | Accession | Reinheit |
|---|---|---|---|
| HY-P71427 | VSNL1 Protein, Human (His) | P62760 (M1-K191) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P76694 | VSNL1 Protein, Human | P62760 (G2-K191) | ≥ 95%, as determined by reducing SDS-PAGE. |
VSNL1 Antibodies
| Art. -Nr. | Produktname | Anwendung | Reactivity |
|---|---|---|---|
| HY-P87142 | VILIP1 Antibody (YA6835) | WB, IHC-P | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Abcd Syndrome |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Dementia, Lewy Body |
|
|
| Schizophrenia |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | VSNL1 | VGNC | VGNC:36841 |
| Felis catus | VSNL1 | VGNC | VGNC:66981 |
| Macaca mulatta | VSNL1 | VGNC | VGNC:106244 |
| Mus musculus | VSNL1 | MGD | MGI:1349453 |
| Rattus norvegicus | VSNL1 | RGD | RGD:3966 |
| Others | VSNL1 | NCBI |