CD1C - CD1c molecule Gene

Also Known as R7; CD1; CD1A; BDCA1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 911

About CD1C

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:158,289,923-158,294,774 (from NCBI)

This gene has 2 transcripts (splice variants), 381 orthologues and 22 paralogues. Broad expression in lymph node (RPKM 8.6), appendix (RPKM 6.9) and 15 other tissues.

Summary

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

CD1C Products (1)

mRNA	Protein	Name
NM_001765.3	NP_001756.2	T-cell surface glycoprotein CD1c precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables endogenous lipid antigen binding	IDA IDA: Inferred from direct assay	21167756	GOA
enables exogenous lipid antigen binding	IDA IDA: Inferred from direct assay	21167756	GOA
enables glycolipid binding	IDA IDA: Inferred from direct assay	21167756	GOA
enables lipopeptide binding	IDA IDA: Inferred from direct assay	21167756	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in T cell activation involved in immune response	IDA IDA: Inferred from direct assay	21167756	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD1C Protein Structure

C1-set

0
100
200
300
333 a.a.

Protein Preferred Names	Protein Names
T-cell surface glycoprotein CD1c	CD1C antigen, c polypeptide

CD1C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	CD1C	P29017	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	CD1C	P29017	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	CD1C	P29017	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	CD1C	P29017	ATXN10	Homo sapiens	Q9UBB4	Y2H Pooling	32814053
Intra	CD1C	P29017	ATXN10	Homo sapiens	Q9UBB4	Validated Y2H	32814053
Intra	CD1C	P29017	ATXN10	Homo sapiens	Q9UBB4	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

CD1C Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P83241	CD1C Antibody (YA2986)	WB	Human
HY-P84241	CD1C Antibody (YA3938)	IHC-P, FC, ELISA	Human
HY-P84241A	CD1C Antibody (YA3938)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Histiocytosis	Chronic Histiocytosis X Hand Schuller Christian Disease Hand-Schüller-Christian Disease Histiocytic Syndrome Histiocytosis, Langerhans-Cell
Follicular Dendritic Cell Sarcoma	Dendritic Cell Sarcoma Dendritic Cell Sarcoma, Follicular Follicular Dendritic Cell Tumour Dendritic Cell Sarcoma, Interdigitating Dendritic Cell Sarcoma, Not Otherwise Specified
Non-Langerhans-Cell Histiocytosis	Histiocytosis, Non-Langerhans-Cell Non-Langerhans Cell Histiocytosis
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Langerhans Cell Sarcoma	Malignant Langerhans Cell Sarcoma
Histiocytic And Dendritic Cell Cancer	Histiocytic And Dendritic Cell
Adult Xanthogranuloma
Rhinoscleroma
Interdigitating Dendritic Cell Sarcoma	Interdigitating Cell Sarcoma Dendritic Cell Sarcoma, Interdigitating Reticulum Cell Sarcoma
Juvenile Xanthogranuloma	Multiple Eruptive Juvenile Xanthogranuloma Naevoxanthoendothelioma Xanthoma Neviforme Xanthogranuloma, Juvenile
Reticulohistiocytic Granuloma	Reticulohistiocytoma Solitary Reticulohistiocytoma Solitary Histiocytoma Solitary Reticulohistiocytosis
Cardiomyopathy, Dilated, 1c, With Or Without Left Ventricular Noncompaction	Left Ventricular Noncompaction 3 Dilated Cardiomyopathy 1c CMD1C Cardiomyopathy, Hypertrophic, 24 Dilated Cardiomyopathy With Left Ventricular Noncompaction Cardiomyopathy, Dilated, 1c, With Or Without Lvnc Cmdc1 Dilated Cardiomyopathy 1c With Or Without Left Ventricular Noncompaction Cardiomyopathy, Dilated 1c, With Or Without Left Ventricular Non-Compaction Cardiomyopathy Dilated With Left Ventricular Noncompaction Cardiomyopathy, Familial Hypertrophic 24 CMH24 Left Ventricular Non-Compaction 3 LVNC3 Cardiomyopathy, Dilated 1c Familial Hypertrophic Cardiomyopathy 24 Cardiomyopathy, Dilated, 1c
Multicentric Reticulohistiocytosis	Lipoid Dermatoarthritis Giant Cell Histiocytomatosis
Erdheim-Chester Disease	Ecd Erdheim Chester Disease Lipoid Granulomatosis Lipid Granulomatosis Polyostotic Sclerosing Histiocytosis
Orbital Cancer	Malignant Neoplasm Of Orbit Orbital Tumor Orbital Neoplasms Neoplasm Of Orbit Proper Orbit Cancer Primary Malignant Neoplasm Of Orbit Intraorbital Cancer
Fibrosarcoma Of Bone	Malignant Histiocytosis Malignant Fibroxanthoma Malignant Fibrous Histiocytoma Histiocytic Medullary Reticulosis Nasal Type Extranodal Nk/T-Cell Lymphoma Histiocytic Sarcoma
Langerhans Cell Histiocytosis	Histiocytosis X Lch Langerhans Cell Granulomatosis Langerhans-Cell Histiocytosis Letterer-Siwe Disease Hashimoto-Pritzger Disease Histiocytosis, Langerhans-Cell Langerhan'S Cell Histiocytosis Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Involving Spleen Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Of Intrapelvic Lymph Nodes Letterer-Siwe Disease Of Intrathoracic Lymph Nodes Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Of Spleen Familial Letterer-Siwe Disease Langerhans-Cell Histiocytosis Nos
Granuloma Annulare	Granulome Annulare Ga - [Granuloma Annulare]
Mycosis Fungoides	Mycosis Fungoides Lymphoma Alibert-Bazin Syndrome Granuloma Fungoides Classic Mycosis Fungoides Mycosis Fungoides, Alibert-Bazin Type
Histiocytosis-Lymphadenopathy Plus Syndrome	H Syndrome Histiocytosis With Joint Contractures And Sensorineural Deafness Faisalabad Histiocytosis Shml Hjcd Rosai-Dorfman Disease Pigmented Hypertrichosis With Insulin-Dependent Diabetes Mellitus Phid Sinus Histiocytosis And Massive Lymphadenopathy Familial Rosai-Dorfman Disease Slc29a3 Spectrum Disorder Sinus Histiocytosis With Massive Lymphadenopathy Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures, And/Or Deafness Hyperpigmentation, Cutaneous, With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss Rosai-Dorfman Disease, Familial Cutaneous Hyperpigmentation With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures And/Or Deafness Rdd Rosaï-Dorfman Disease Slc29a3 Disorder Destombes-Rosai-Dorfman Disease Rosai-Dorfman-Destombes Disease HLAS Cutaneous Hyperpigmentation With Hypertrichosis Hepatosplenomegaly Heart Anomalies And Hypogonadism With Or Without Hearing Loss Histiocytosis And Lymphadenopathy With Or Without Cutaneous Cardiac And/Or Endocrine Features Joint Contractures And/Or Deafness H Disease Sinus Histiocytosis
Cobblestone Retinal Degeneration	Paving Stone Retinal Degeneration Paving Stone Degeneration Of Retina
Spongiotic Dermatitis
Polyclonal Hypergammaglobulinemia	Polyclonal Gammopathy
Lymphoid Interstitial Pneumonia	Lymphocytic Interstitial Pneumonia Lip Disease Lip Diseases LIP Disease Of Lips
Granulomatous Dermatitis
Histiocytic Sarcoma	Malignant Histiocytosis
Exophthalmos	Proptosis
Seborrheic Dermatitis	Seborrhoeic Dermatitis Seborrhea Seborrhoeic Eczema Skin Seborrheic Dermatitis, Seborrheic
Central Diabetes Insipidus	Neurogenic Diabetes Insipidus Diabetes Insipidus Cranial Type Diabetes Insipidus Neurogenic Diabetes Insipidus Neurohypophyseal Neurohypophyseal Diabetes Insipidus Pituitary Diabetes Insipidus Cdi Doid:0081055 Diabetes Insipidus Di - [Diabetes Insipidus] Adh - [Antidiuretic Hormone Secretion] Deficiency Diabetes Mellitus Insipidus Familial Diabetes Insipidus Antidiuretic Hormone Hyposecretion Vasopressin Deficiency Syndrome Primary Central Diabetes Insipidus Vasopressin Deficiency Vasopressin Hyposecretion Diabetes Insipidus Secondary To Vasopressin Deficiency
Orbital Disease	Orbit Orbital Diseases
Malignant Histiocytic Disease	Histiocytic Disorders, Malignant
Dendritic Cell Thymoma	Epithelioid Thymoma Type B Thymoma
Large Cell Acanthoma
Frontal Sinus Benign Neoplasm	Neoplasm Of Frontal Sinus Tumor Of The Frontal Sinus
Lichen Disease
Otorrhea	Discharging Ear
Connective Tissue Benign Neoplasm	Soft Tissue Neoplasms Mesenchymal Tissue Neoplasm Neoplasm Of Soft Tissue Neoplasm Of Soft Tissues Soft Tissue Benign Neoplasm Tumor Of The Soft Tissue Soft Tissue Neoplasm
Cervical Adenoid Cystic Carcinoma	Adenoid Cystic Carcinoma Of The Cervix Uteri
Beach Ear	Acute Swimmer'S Ear Acute Bacterial Inflammation Of External Ear Acute Otitis Externa, Diffuse Acute Swimmers' Ear Tank Ear
Keratosis, Seborrheic	Seborrheic Keratosis Keratosis, Seborrheic, Somatic Basal Cell Papilloma Keratosis Seborrheica KERSEB
Balloon Cell Malignant Melanoma
Diencephalic Astrocytoma	Astrocytoma Of Diencephalon
T-Cell Prolymphocytic Leukemia	T Cell Prolymphocytic Leukemia Prolymphocytic Leukemia, T-Cell Type T-Pll T-Cell Chronic Lymphocytic Leukemia Lymphocytic Leukemia T-Cell Chronic Doid:0081042 Leukemia, T-Cell, Chronic Prolymphocytic Leukaemia Of T-Cell Type Without Mention Of Remission
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculoma Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Vulvar Proximal-Type Epithelioid Sarcoma
Central Epithelioid Sarcoma	Proximal-Type Epithelioid Sarcoma
Hypersensitivity Reaction Type Iv Disease	Immunoproliferative Disorders Immunoproliferative Disease
Thymus Gland Disease	Disease Of Thymus Gland
Thymus Cancer	Thymic Neoplasm Thymic Tumor Thymus Neoplasm Thymus Neoplasms Malignant Neoplasm Of Thymus Neoplasm Of Thymus Thymic Neoplasms Thymoma, Familial Thymic Carcinoma Thymoma, Type C Cancer Of Thymus Malignant Tumour Of Thymus Primary Malignant Neoplasm Of Thymus Thymic Glandular Cancer Thymus Gland Cancer
Leprosy 3	Leprosy Leprosy, Susceptibility To, 3 Hansen'S Disease Leprosy, Susceptibility To Hansen Disease Infection Due To Mycobacterium Leprae LPRS3 Leprosy, Type 3 Anaesthesia Leprosy Anaesthetic Leprosy Maculoanaesthetic Leprosy Macular Leprosy Leprosy Unspecified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS02201	CD1C Human Pre-designed siRNA Set A	Inhibitor	/	Unkown