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Art. -Nr.: HY-16259

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Indecainide hydrochloride

(Synonyms: Ricainide hydrochloride; LY 135837)

Indecainide hydrochloride is a potent and orally active class I local anesthetic antiarrhythmic agent. Indecainide hydrochloride has Na⁺-channel-blocking activity.

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CAS. Nr.: 73681-12-6
Formel: C₂₀H₂₅ClN₂O
Molecular Weight:344.88

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Indecainide hydrochloride Chemical Structure

CAS. Nr.: 73681-12-6

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Indecainide hydrochloride is a potent and orally active class I local anesthetic antiarrhythmic agent. Indecainide hydrochloride has Na⁺-channel-blocking activity^[1]^[2]^[3].

Alle Sodium Channel Isoform-spezifische Produkte anzeigen :

In Vivo

Indecainide hydrochloride (0, 3, 6, or 9 mg/kg; IV, daily for 1 month) causes 6 of 10 male rats and 1 of 10 female rats die at 9 mg/kg during the test period^[2].
Indecainide hydrochloride (0, 1.5, 3, or 4.5 mg/kg; IV, daily for 1 month) causes 2 of 4 dogs die at 4.5 mg/kg; exhibits no overt signs of toxicity and no hematologic, serum chemistry or histologic changes at 1.5 or 3 mg/kg^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 73681-12-6
Molecular Weight 344.88
Formel C₂₀H₂₅ClN₂O
SMILES

O=C(C1(CCCNC(C)C)C2=C(C3=C1C=CC=C3)C=CC=C2)N.Cl
Synonyms

Ricainide hydrochloride; LY 135837
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Steinberg MI, et al. Electrophysiological studies of indecainide hydrochloride, a new antiarrhythmic agent, in canine cardiac tissues. J Cardiovasc Pharmacol. 1984 Jul-Aug;6(4):614-21. [Content Brief]

[2]. Sandusky GE Jr, et al. Toxicology of indecainide hydrochloride after intravenous administration to rats and dogs. Toxicol Lett. 1985 Aug;26(2-3):107-10. [Content Brief]

[3]. D R Holland, et al. Indecainide: effects on arrhythmias, electrophysiology, and cardiovascular dynamics. J Cardiovasc Pharmacol. 1989 Sep;14(3):454-61. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Indecainide hydrochloride

Alle Sodium Channel Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Indecainide hydrochloride Related Classifications

HY-16259 Related Classifications