Art. -Nr.: HY-126397

MnTBAP chloride

6 Cited Publications

Kundenbewertung

Based on 6 publication(s) in Google Scholar

MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research.

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Reinheit: 98.0%
CAS. Nr.: 55266-18-7
Formel: C₄₈H₂₈ClMnN₄O₈
Molecular Weight:879.15

Speicherung:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

MnTBAP chloride Chemical Structure

CAS. Nr.: 55266-18-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (6)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]^[2]

NFκB

Alle NF-κB Isoform-spezifische Produkte anzeigen :

In Vitro

MnTBAP chloride (pretreated 1.14 μM before TGF-β1 of 10 ng/mL) partially but significantly restores E-cadherin reduction and suppresses the induction of α-SMA and vimentin in immortalized mouse proximal tubular cells (mPTCs)^[1].
MnTBAP chloride (50 μM; 6 hours) increases BMPR-II mRNA by 1.3-fold at 2 h, but does not affect protein expression of BMPR-II during a time course of 16 h in HUVECs. MnTBAP chloride increases phosphorylation of Smad 1/5, suggesting modulation of the BMP signaling pathway^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MnTBAP chloride (10 mg/kg; IP; three times per week for twelve weeks) attenuates renal fibrosis in 5/6 Nx mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J mice with 5/6 nephrectomy (Nx)^[1]
Dosage:

10 mg/kg
Administration:

IP; three times per week for twelve weeks
Result:

Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys.

Chemical Information

CAS. Nr. 55266-18-7
Appearance Solid
Molecular Weight 879.15
Formel C₄₈H₂₈ClMnN₄O₈
Color Brown to black
SMILES

[Cl-][Mn+3]12([N](C(C=C3)=C4C(C=C5)=CC=C5C(O)=O)=C3C(C(C=C6)=CC=C6C(O)=O)=C7C=C8)[N-]7C8=C(C(C=C9)=CC=C9C(O)=O)C%10=[N]1C(C=C%10)=C(C(C=C%11)=CC=C%11C(O)=O)C%12=CC=C4[N-]2%12
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (6)

All Histological Imaging/StainingCell Imaging/StainingRT-PCRIFWB

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Journal Impact Factor

Redox Biol

Endothelial Lon protease 1 facilitates the redox balance to prevent glomerulosclerosis by acting on superoxide dismutase 2 ubiquitination. [Abstract]

2025 Dec:88:103929. PMID: 41275592
Adv Compos Hybrid Mater

2025 Feb 04.
J Immunother Cancer

Macrophage NLRP3 activation and IL-1β release drive osimertinib-induced antitumor immunity. [Abstract]

2025 Oct 5;13(10):e012182. PMID: 41052880
Free Radic Biol Med

A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial ROS-mediated ferroptosis. [Abstract]

2023 Jan:194:84-98. PMID: 36403736

MnTBAP chloride purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2023 Jan:194:84-98. [Abstract]

The decreased protein expression levels of the ferroptosis repressors NRF2, SLC7A11, and GPX4 after cisplatin stimuli are rescued by 84-B10 (40 µM), MnTBAP (80 µM), and Lipro-1 (2 µM) pretreat for 2 h, in TKPT cells.
Biochem Pharmacol

MnTBAP attenuates pulmonary hypertension-induced right ventricular dysfunction and remodeling by modulating the CaMKIIδ-SERCA2a signaling pathway. [Abstract]

2026 Mar 21:249:117920. PMID: 41871719

MnTBAP chloride purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2026 Mar 21:249:117920. [Abstract]

Pulmonary arteriole morphology and wall area were estimated by H&E staining treated with MnTBAP (10 mg/kg, i.p.).

MnTBAP chloride purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2026 Mar 21:249:117920. [Abstract]

Myocardial cell size was measured by WGA staining treated with MnTBAP (10 mg/kg, i.p.).

MnTBAP chloride purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2026 Mar 21:249:117920. [Abstract]

MnTBAP (10 mg/kg, i.p.) treatment partially prevented the upregulation of the mRNA expression of inflammation.

MnTBAP chloride purchased from MedChemExpress. Usage Cited in: Biochem Pharmacol. 2026 Mar 21:249:117920. [Abstract]

Immunofluorescence staining of myocardial sections for p-CaMKIIδ Thr287 (red) and DAPI (blue) is shown treated with MnTBAP (10 mg/kg, i.p.).
J Inorg Biochem

Insight into the interaction of heme with human calcitonin (hCT) and its inhibitory effect on hCT aggregation. [Abstract]

2026 Jul:280:113319. PMID: 41911648

Lösungsmittel & Löslichkeit

In Vitro:

1 M NaOH : 100 mg/mL (113.75 mM; Need ultrasonic)

0.5 M NaOH : 20 mg/mL (22.75 mM; Need ultrasonic and warming)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1375 mL

5.6873 mL

11.3746 mL

5 mM

0.2275 mL

1.1375 mL

2.2749 mL

10 mM

0.1137 mL

0.5687 mL

1.1375 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Jing Yu, et al. MnTBAP Therapy Attenuates Renal Fibrosis in Mice With 5/6 Nephrectomy. Oxid Med Cell Longev. 2016;2016:7496930. [Content Brief]

[2]. Qian Zhou, et al. MnTBAP Increases BMPR-II Expression in Endothelial Cells and Attenuates Vascular Inflammation. Vascul Pharmacol. 2016 Sep;84:67-73. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
0.5 M NaOH / 1 M NaOH	1 mM	1.1375 mL	5.6873 mL	11.3746 mL	28.4366 mL
	5 mM	0.2275 mL	1.1375 mL	2.2749 mL	5.6873 mL
	10 mM	0.1137 mL	0.5687 mL	1.1375 mL	2.8437 mL
	15 mM	0.0758 mL	0.3792 mL	0.7583 mL	1.8958 mL
	20 mM	0.0569 mL	0.2844 mL	0.5687 mL	1.4218 mL
1 M NaOH	25 mM	0.0455 mL	0.2275 mL	0.4550 mL	1.1375 mL
	30 mM	0.0379 mL	0.1896 mL	0.3792 mL	0.9479 mL
	40 mM	0.0284 mL	0.1422 mL	0.2844 mL	0.7109 mL
	50 mM	0.0227 mL	0.1137 mL	0.2275 mL	0.5687 mL
	60 mM	0.0190 mL	0.0948 mL	0.1896 mL	0.4739 mL
	80 mM	0.0142 mL	0.0711 mL	0.1422 mL	0.3555 mL
	100 mM	0.0114 mL	0.0569 mL	0.1137 mL	0.2844 mL

Keywords

MnTBAP chloride

6 Cited Publications

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MnTBAP chloride

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Publications Citing Use of MedChemExpress (MCE) MnTBAP chloride

Alle NF-κB Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (6)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MnTBAP chloride Related Classifications

HY-126397 Related Classifications