PEAK
PEAK proteins (PEAK1/SGK269, PEAK2/SGK223, and PEAK3) form a family of large cytoplasmic pseudokinases whose kinase-related domains lack catalytic activity yet serve as regulated signaling scaffolds. PEAK1 localizes to focal adhesions, binds Grb2 and 14-3-3 proteins, and modulates integrin, ERK, and SRC signaling that drives cell migration and proliferation. PEAK members are frequently overexpressed in cancers, including breast and colorectal tumors, where they support metastatic behavior and resistance to targeted agents. Because they act as signaling hubs rather than enzymes, they are attractive but challenging drug targets. Recombinant PEAK proteins are used for interaction studies, antibody generation, and phosphoproteomic work.
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PEAK Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
