TTK
TTK, the human homolog of yeast Mps1, is a dual-specificity kinase that functions as the initiator and core engine of the spindle assembly checkpoint. It accumulates on unattached kinetochores, where it phosphorylates KNL1 and other substrates to recruit Bub1, BubR1 and the Mad1-Mad2 complex, generating the wait-anaphase signal. TTK also participates in chromosome biorientation, error correction and mitotic exit. Because checkpoint signaling depends critically on TTK, its inhibition causes premature anaphase and massive aneuploidy, and TTK is overexpressed in breast, liver and other cancers. Clinical inhibitors such as BAY-1161909 underscore its therapeutic relevance. Recombinant TTK serves checkpoint and drug-discovery studies.
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TTK Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
