YM-750 (Standard)
YM-750 (Standard) is the analytical standard of YM-750 (HY-107396). This product is intended for research and analytical applications. YM-750 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A.
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- CAS. Nr.: 138046-43-2
- Formel: C31H36N2O
- Molecular Weight:452.63
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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HY-107396
YM-750ACAT Inhibitor -
HY-107572
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HY-13823
C646p300/CBP HAT Inhibitor -
HY-107571
VULM 1457Acyl-CoA Inhibitor -
HY-100400A
K-604 dihydrochlorideACAT1 Inhibitor -
HY-107572R
PD 128042 (Standard)ACAT/LPAT Inhibitor -
HY-B0034
Donepezil HydrochlorideAChE Inhibitor -
HY-107570
IWP-12Acyltransferase Inhibitor -
HY-107569
GarcinolAChE Inhibitor -
HY-124960
CTPBHistone Acetyltransferase Activator
Biologische Aktivität
Beschreibung
Chemical Information
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CAS. Nr. 138046-43-2
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Molecular Weight 452.63
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Formel C31H36N2O
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SMILES
O=C(NC1=C(C)C=C(C)C=C1C)N(C2CCCCCC2)CC3=CC(CC4=C5C=CC=C4)=C5C=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
[1]. Nagata Y, et al. N-[2-[N'-pentyl-(6,6-dimethyl-2,4-heptadiynyl)amino]ethyl]- (2-methyl-1-naphthylthio)acetamide (FY-087). A new acyl coenzyme a:cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice. Biochem Pharmacol. 1995;49(5):643-651. [Content Brief]
[2]. Chang C, et al. Human acyl-CoA:cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis. Acta Biochim Biophys Sin (Shanghai). 2006;38(3):151-156. [Content Brief]
[3]. Miike T, et al. Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells. Life Sci. 2008;82(1-2):79-84. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
YM-750 (Standard) Related Classifications
HY-107396R Related Classifications
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