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ZHX1 - zinc fingers and homeoboxes 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11244

About ZHX1

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:123,248,456-123,275,541 (from NCBI)

This gene has 8 transcripts (splice variants), 242 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 19.7), esophagus (RPKM 16.5) and 25 other tissues.

Summary

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011]

ZHX1 Products (2)

mRNA	Protein	Name
NM_001017926.3	NP_001017926.1	zinc fingers and homeoboxes protein 1
NM_007222.5	NP_009153.3	zinc fingers and homeoboxes protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12237128	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10571058	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	12659632	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12237128	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17303076	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in nucleus	IDA IDA: Inferred from direct assay	17056598	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12237128	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZHX1 Protein Structure

Homeobox

Homez

0
200
400
600
800
873 a.a.

Protein Preferred Names	Protein Names
zinc fingers and homeoboxes protein 1	zinc finger and homeodomain protein 1

ZHX1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZHX1	Q9UKY1	ZMYND11	Homo sapiens	Q15326	Y2H	21988832
Intra	ZHX1	Q9UKY1	DNMT3B	Homo sapiens	Q9UBC3-1	Anti Tag CoIP	17303076
Intra	ZHX1	Q9UKY1	DNMT3B	Homo sapiens	Q9UBC3-1	Y2H	17303076
Intra	ZHX1	Q9UKY1	DNMT3B	Homo sapiens	Q9UBC3-1	Imaging	17303076
Intra	ZHX1	Q9UKY1	DNMT3B	Homo sapiens	Q9UBC3-1	Pull Down	17303076
Intra	ZHX1	Q9UKY1	ATXN1	Homo sapiens	P54253	Y2H	16713569
Intra	ZHX1	Q9UKY1	ZHX2	Homo sapiens	Q9Y6X8	Anti Tag CoIP	26496610
Intra	ZHX1	Q9UKY1	ZHX2	Homo sapiens	Q9Y6X8	Pull Down	12741956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Trichorhinophalangeal Syndrome, Type Ii	Langer-Giedion Syndrome Lgs Trichorhinophalangeal Syndrome Type Ii Trichorhinophalangeal Syndrome Type 2 TRPS2 Monosomy 8q24.1 Chromosome 8q24.1 Deletion Syndrome Deletion 8q24.1 Giedion-Langer Syndrome Trichorhinophalangeal Dysplasia Type Ii Langer Giedion Syndrome Trps 2 Tricho-Rhino-Phalangeal Syndrome Type Ii Trichorhinophalangeal Syndrome With Exostosis Trps Ii Tricho-Rhino-Phalangeal Syndrome 2 8q24.1 Microdeletion Syndrome 8q24.1 Deletion Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16068	ZHX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZHX1	RGD	RGD:620010
Bos taurus	ZHX1	VGNC	VGNC:37182
Mus musculus	ZHX1	MGD	MGI:109271
Canis familiaris	ZHX1	VGNC	VGNC:48631
Macaca mulatta	ZHX1	VGNC	VGNC:78828
Felis catus	ZHX1	VGNC	VGNC:67243
Others	ZHX1	NCBI