Hydrocortisone phosphate
Hydrocortisone phosphate (Hydrocortisone 21-phosphate) is a derivative of the glucocorticoid Hydrocortisone hemisuccinate (HY-B1402) that increases serum luteinizing hormone (LH) levels. Hydrocortisone phosphate increases the activity of magnesium-dependent polymerases in the nucleolus. Hydrocortisone phosphate also serves as a substrate for alkaline phosphatase to localize phosphatases that hydrolyze steroid phosphates, and the role of alkaline phosphatase has been validated in adult mouse tissues.
For research use only. We do not sell to patients.
- CAS No.: 3863-59-0
- Formula: C21H31O8P
- Molecular Weight:442.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-17463
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HY-17463R
Prednisolone (Standard) -
HY-17358
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HY-13693
Mometasone furoateGlucocorticoid Receptor Agonist -
HY-B0328
TriamcinoloneSHRs Agonist -
HY-B1540
BeclometasoneGlucocorticoid Receptor Agonist
Biological Activity
Description
Chemical Information
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CAS No. 3863-59-0
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Molecular Weight 442.44
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Formula C21H31O8P
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SMILES
C[C@@]12[C@](C(COP(O)(O)=O)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
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Synonyms
Hydrocortisone 21-phosphate; Cortisol 21-phosphate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
Purity & Documentation
References
[1]. Botte V, et al. "The hydrocortisone 21-phosphate as substrate for alkaline phosphatase: Histochemical remarks." Histochemie 16.2 (1968): 195-196. [Content Brief]
[2]. Jacob, et al. Munro. "Regulation of nucleolar RNA metabolism by hydrocortisone." European Journal of Biochemistry 7.4 (1969): 449-453. [Content Brief]
[3]. Kowalski, et al. "Effects of subchronic implantation of hydrocortisone phosphate-releasing osmotic pumps on peripheral gonadotropin levels and estradiol feedback to gonadotropin secretion in the cynomolgus monkey." Neuroendocrinology 57.2 (1993): 330-339. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Hydrocortisone phosphate Related Classifications
HY-B1155 Related Classifications
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