N,N-Dimethylacetamide
Based on 1 publication(s) in Google Scholar
N,N-Dimethylacetamide (DMAc) is an organic solvent with blood-brain transmissibility and an FDA-approved drug excipient. N, N-dimethylacetamide exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. N, N-dimethylacetamide can be used in studies of weight gain caused by a high-fat diet and neuroinflammation in Alzheimer's disease.
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- Pureté : 99.96%
- CAS No.: 127-19-5
- Formule: C4H9NO
- Masse moléculaire:87.12
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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HY-Y1893
Solutol HS-15 -
HY-Y0873A
PEG400 -
HY-Y1275
N-MethylpyrrolidoneFive-membered Cyclic Amide -
HY-Y0320
Dimethyl sulfoxide, meets analytical specification of Ch.P.Aprotic Solvent -
HY-Y0320C
Dimethyl sulfoxideAprotic Solvent -
HY-Y0320D
Dimethyl sulfoxide, cryoprotectant vitrification agentBiochemical Assay Reagent -
HY-Y1891
Tween 80 -
HY-W011500
TCEP hydrochlorideNon-Thiol Reducing Agent -
HY-Y0320R
Dimethyl sulfoxide (Standard)Aprotic Solvent -
HY-Y0320GL
Dimethyl sulfoxide (GMP Like)GMP Like class DMSO -
HY-B1659
GlycerolEndogenous Metabolite
Publications Citing Use of MedChemExpress (MCE) N,N-Dimethylacetamide
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Activité biologique
Description
In Vitro
N,N-Dimethylacetamide (10-1000 μM, 24 h) inhibits the bactericidal activity of macrophages in RAW 264.7 cells[1].
N,N-Dimethylacetamide (0.1-10 mM, 2 h) inhibits Aβ-induced inflammation in microglia cell lines SIM-A9 and HMC3[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SIM-A9, HMC3
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Concentration:0.1, 1, 10 mM
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Incubation Time:2 h
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Result:Diminished iNOS production.
Decreased Aβ42 in a concentration-dependent manner.
Reduced APP and p-APP protein levels at 1 and 10 mM.
Increased IκBα levels in SIM-A9 cells with both 1 mM and 10 mM and in HMC3 cells with 10 mM.
In Vivo
N,N-Dimethylacetamide (2.1 g/kg/day, intraperitoneally administered) attenuates the clinical and histological features of DSS-induced colitis[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LPS-Triggered PTB and Spontaneous Abortions mice[1]
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Dosage:0.2, 0.39, 0.78, 1.56, 3,1 mg/kg
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Administration:i.p. Single dose
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Result:Attenuated the excessive endotoxin-triggered proinflammatory response that leads to preterm delivery.
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Animal Model:DSS-induced colitis in C57Bl/6 mice[3]
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Dosage:2.1 g/kg
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Administration:i.p. once a day for four days
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Result:Attenuated inflammation, crypt injury and ulceration.
Chemical Information
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CAS No. 127-19-5
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Appearance Liquid (Density: 0.937 g/cm3)
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Masse moléculaire 87.12
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Formule C4H9NO
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Color Colorless to light yellow
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SMILES
CC(N(C)C)=O
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Synonyms
DMAc
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Rep
Heat shock factor 1 inhibition enhances the effects of modulated electro hyperthermia in a triple negative breast cancer mouse model. [Abstract]2024 Apr 8;14(1):8241. PMID: 38589452
Solvant et solubilité
In Vitro:
DMSO : ≥ 100 mg/mL (1147.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Pureté et documentation
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Fiche technique (274 KB)
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SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Korean - KR (761 KB)
- Portuguese - PT (761 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Sundaram S, et al. N,N-dimethylacetamide regulates the proinflammatory response associated with endotoxin and prevents preterm birth. Am J Pathol. 2013 Aug;183(2):422-30. [Content Brief]
[2]. Wei ZH, et al. N,N-dimethylacetamide targets neuroinflammation in Alzheimer's disease in in-vitro and ex-vivo models. Sci Rep. 2023 May 1;13(1):7077. [Content Brief]
[3]. Koya JB, et al. FDA-Approved Excipient N, N-Dimethylacetamide Attenuates Inflammatory Bowel Disease in In Vitro and In Vivo Models. Fortune J Health Sci. 2022;5:499-509. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 11.4784 mL | 57.3921 mL | 114.7842 mL | 286.9605 mL |
| 5 mM | 2.2957 mL | 11.4784 mL | 22.9568 mL | 57.3921 mL | |
| 10 mM | 1.1478 mL | 5.7392 mL | 11.4784 mL | 28.6961 mL | |
| 15 mM | 0.7652 mL | 3.8261 mL | 7.6523 mL | 19.1307 mL | |
| 20 mM | 0.5739 mL | 2.8696 mL | 5.7392 mL | 14.3480 mL | |
| 25 mM | 0.4591 mL | 2.2957 mL | 4.5914 mL | 11.4784 mL | |
| 30 mM | 0.3826 mL | 1.9131 mL | 3.8261 mL | 9.5654 mL | |
| 40 mM | 0.2870 mL | 1.4348 mL | 2.8696 mL | 7.1740 mL | |
| 50 mM | 0.2296 mL | 1.1478 mL | 2.2957 mL | 5.7392 mL | |
| 60 mM | 0.1913 mL | 0.9565 mL | 1.9131 mL | 4.7827 mL | |
| 80 mM | 0.1435 mL | 0.7174 mL | 1.4348 mL | 3.5870 mL | |
| 100 mM | 0.1148 mL | 0.5739 mL | 1.1478 mL | 2.8696 mL |
N,N-Dimethylacetamide Related Classifications
HY-W042416 Related Classifications
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