Formycin A
Based on 1 Customer Validation
Formycin A (NSC 102811), a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM. Formycin A shows antitumor and antiviral activities.
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- Pureté: 99.0%
- CAS No.: 6742-12-7
- Formule: C10H13N5O4
- Masse moléculaire:267.24
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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HIV-1 10 μM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L1210 | IC50 |
1 μM
Compound: formycin A
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Cytotoxic concentration required to reduce rate of L1210 cell proliferation after 48 hr
Cytotoxic concentration required to reduce rate of L1210 cell proliferation after 48 hr
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[PMID: 4068000] |
| MDCK | CC50 |
2.6 μM
Compound: 7; FMA
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Cytotoxicity against dog MDCK cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter96 Aqueous one solution assay
Cytotoxicity against dog MDCK cells assessed as reduction in cell viability incubated for 48 hrs by CellTiter96 Aqueous one solution assay
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[PMID: 35092894] |
| S49 | IC50 |
9.3 μM
Compound: 1
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Compound evaluated for the inhibitory concentration of S49 Mouse Lymphoma T-cells
Compound evaluated for the inhibitory concentration of S49 Mouse Lymphoma T-cells
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[PMID: 3874961] |
Formycin A (NSC 102811; 1 μM, 5 μM, 10 μM) antagonizes Zidovudine (AZT; a dideoxynucleoside chain terminator).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 6742-12-7
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Appearance Solid
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Masse moléculaire 267.24
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Formule C10H13N5O4
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Color White to off-white
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SMILES
O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)C2=NNC3=C2N=CN=C3N
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Synonyms
NSC 102811
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (270 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Dapp MJ , et al. Discovery of novel ribonucleoside analogs with activity against human immunodeficiency virus type 1.J Virol. 2014 Jan;88(1):354-63. [Content Brief]
[2]. Zhang M, et al. Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C-Nucleoside Scaffolds. Appl Environ Microbiol. 2020 Jan 7;86(2). [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Formycin A Related Classifications
HY-102026 Related Classifications
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