F10 - coagulation factor X Gene
Also Known as FX; FXA
Species: Homo sapiens
About F10
This gene has 7 transcripts (splice variants), 236 orthologues, 16 paralogues and is associated with 2 phenotypes. Broad expression in liver (RPKM 44.8), ovary (RPKM 13.4) and 16 other tissues.
Summary
This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the Other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by Factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to Thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]
F10 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_000504.4 | NP_000495.1 | coagulation factor X isoform 1 preproprotein |
| NM_001312674.2 | NP_001299603.1 | coagulation factor X isoform 2 precursor |
| NM_001312675.2 | NP_001299604.1 | coagulation factor X isoform 3 precursor |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables phospholipid binding |
IDA
IDA: Inferred from direct assay
|
17469850 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
6323392 | GOA |
| enables serine-type endopeptidase activity |
IDA
IDA: Inferred from direct assay
|
17469850 | GOA |
| enables serine-type endopeptidase activity |
IMP
IMP: Inferred from mutant phenotype
|
12574802 | GOA |
| Biological Process GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| involved in positive regulation of TOR signaling |
IDA
IDA: Inferred from direct assay
|
18612547 | GOA |
F10 Protein Structure
Gla: Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain (45 - 86)
EGF: EGF-like domain (90 - 120)
FXa_inhibition: Coagulation Factor Xa inhibitory site (129 - 164)
Trypsin: Trypsin (235 - 462)
- 0
- 100
- 200
- 300
- 400
- 488 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
coagulation factor X |
|
F10 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | Références |
|---|---|---|---|---|---|---|---|
|
Intra
|
F10 | P00742 | NOTCH2NLC | Homo sapiens | P0DPK4 | 32296183 | |
|
Intra
|
F10 | P00742 | NOTCH2NLC | Homo sapiens | P0DPK4 | 32296183 | |
|
Intra
|
F10 | P00742 | NOTCH2NLC | Homo sapiens | P0DPK4 | 32296183 | |
|
Intra
|
F10 | P00742 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
F10 | P00742 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 | |
|
Intra
|
F10 | P00742 | UBQLN2 | Homo sapiens | Q9UHD9 | 32296183 |
Recombinant F10 Proteins
| Cat. No. | Nom du produit | Accession | Pureté |
|---|---|---|---|
| HY-P7860 | Coagulation Factor X/F10 Protein, Human (HEK293, Fc) | P00742 (N32-K488) | ≥ 90%, as determined by reducing SDS-PAGE. |
F10 Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P81604 | Factor X Antibody (YA1349) | WB, IHC-P | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Factor X Deficiency |
|
|
| Hemophilia B |
|
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| Scott Syndrome |
|
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| Hemorrhagic Disease |
|
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| Hemophilia A |
|
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| Carotid Artery Thrombosis |
|
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| Hemarthrosis |
|
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| Antithrombin Iii Deficiency |
|
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| Myocardial Infarction |
|
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| Thrombocytopenia |
|
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| Hemophilia |
|
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| Antiphospholipid Syndrome |
|
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| Thrombosis |
|
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| Thrombophilia |
|
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| Prothrombin Deficiency, Congenital |
|
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| Factor V Deficiency |
|
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| Thrombophilia Due To Thrombin Defect |
|
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| Factor Vii Deficiency |
|
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| Quebec Platelet Disorder |
|
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| Thrombophilia Due To Activated Protein C Resistance |
|
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| Atrial Fibrillation |
|
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| Protein Z Deficiency |
|
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| Protein S Deficiency |
|
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| Pulmonary Embolism |
|
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| Afibrinogenemia, Congenital |
|
|
| Disseminated Intravascular Coagulation |
|
|
| Glanzmann Thrombasthenia 1 |
|
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| Blood Platelet Disease |
|
|
| Puerperal Pulmonary Embolism |
|
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| Acute Myocardial Infarction |
|
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| Viral Hepatitis |
|
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| Pulmonary Artery Disease |
|
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| Brachydactyly, Type D |
|
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| Factor Viii Deficiency |
|
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| Intracranial Thrombosis |
|
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| Gastroduodenal Crohn'S Disease |
|
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| Post-Thrombotic Syndrome |
|
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| Prothrombin Deficiency |
|
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| Factor Xi Deficiency |
|
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| Temporal Lobe Neoplasm |
|
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| Peroxisome Biogenesis Disorder 11a |
|
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| Blood Coagulation Disease |
|
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| Stroke, Ischemic |
|
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| Heart Conduction Disease |
|
|
| Alpha-2-Plasmin Inhibitor Deficiency |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Patent Foramen Ovale |
|
|