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Cat. No.: HY-W451415

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NHS-PEG-NHS

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NHS-PEG-NHS is a derivative of activated polyethylene glycol (PEG) that can modify functional groups on protein surfaces via covalent binding. NHS-PEG-NHS serves as a bioconjugation modification reagent for modifying proteins, enzymes, peptides and antibodies.

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Pureté: ≥95.0%
CAS No.: 122375-06-8
Formule: (C₂H₄O)_nC₁₀H₈N₂O₉

Stockage:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

NHS-PEG-NHS Chemical Structure

CAS No.: 122375-06-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

In Vitro

NHS-PEG-NHS (Compound 13) (24-72 h) shows an activation rate of 88% and polydispersity of 1.03 in vitro assays, indicating stable covalent binding to protein functional groups, and demonstrates selective PEGylation efficiency in protein modification experiments, reducing immunogenicity and prolonging biomolecule half-life^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 122375-06-8
Appearance Solid
Formule (C₂H₄O)_nC₁₀H₈N₂O₉
SMILES

O=C(OCCOC(ON1C(CCC1=O)=O)=O)ON2C(CCC2=O)=O.[n]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Tateishi N, et al. Method for producing activated polyethylene glycol derivative. WIPO (PCT), WO2024203596A1. 2024-10-03.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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