ULK1-IN-3
ULK1-IN-3 (Compound 8) is a novel chromone-based as a potential inhibitor of ULK1. ULK1-IN-3 inhibits cell cycle, autophagy and induces apoptosis, oxidative stress in colon cancer cell lines.
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- Formule: C25H21ClO5
- Masse moléculaire:436.88
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Activité biologique
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ULK1 |
ULK1-IN-3 (0-20 μM, 72 h) shows an effective growth inhibitor against 786-O, MCF-7, SW620 and T-24 colon cancer cell lines, most effective against SW620 cells with a LC50 value of 3.2 μM, slightly surpassing 5-Fluorouracil (HY-90006)[1].
ULK1-IN-3 (1.25-10 μM, 24 h) induces G2/M and S phase cell arrest in SW620 cells[1].
ULK1-IN-3 (1.25-5 μM, 48 h) triggers the intrinsic apoptotic pathway, potentially by elevating the production of ROS in SW620 cells. Additionally, ULK1-IN-3 up-regulates cleaved PARP (cPARP) and the expression of NFκβ and AMPK, but down-regulates the expression of the AKT in SW620 cells[1].
LC50 values of ULK1-IN-3 for the inhibition of cancer cell viability[1]
| Compounds | 786-O | MCF-7 | SW620 | T-24 |
| ULK1-IN-3 | 4.5±0.15 | 4.3±1.90 | 3.2±0.10 | 3.5±0.42 |