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Cat. No.: HY-P11867

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UM206_L

UM206_L is a linear Wnt fragment peptide derived from conserved Wnt3a/Wnt5a sequences, inactive in soluble form but capable of activating canonical Wnt/β-catenin signaling when conjugated to magnetic nanoparticles and exposed to a high-gradient, time-varying magnetic field or immobilized on glass surfaces.

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CAS No.: 1242439-00-4
Formule: C₅₄H₉₀N₁₆O₂₃S₃
Masse moléculaire:1427.58

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Please store the product under the recommended conditions in the Certificate of Analysis.

Synthèse personnalisée de peptides

UM206_L Chemical Structure

CAS No.: 1242439-00-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Wnt :

In Vitro

UM206_L (free form) (10 nM-1 mM; 3 h, 24 h) fails to stably regulate the canonical Wnt/β-catenin TCF/LEF signaling pathway in HEK293 Luc-TCF/LEF cells^[1].
UM206_L-conjugated MNPs (1-10 µg per mg MNP; 1-24 h), when combined with 1 Hz nanomagnetic actuation, potently activate the canonical Wnt/β-catenin TCF/LEF signaling pathway in HEK293 Luc-TCF/LEF cells in a peptide density-dependent manner in vitro^[1].
UM206_L (immobilized; 1 µg per slide; 3-24 h) retains weak canonical Wnt/β-catenin TCF/LEF signaling activity in HEK293 Luc-TCF/LEF cells on glass substrates, induces a significant increase in signaling at 3 h, and this signaling level is maintained until 24 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1242439-00-4
Masse moléculaire 1427.58
Formule C₅₄H₉₀N₁₆O₂₃S₃
Sequence

Ac-Cys-Asn-Lys-Thr-Ser-Glu-Gly-Met-Asp-Gly-Cys-Glu-Leu-NH2
Sequence Shortening

Ac-CNKTSEGMDGCEL-NH2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Hu B, et al. Immobilization of Wnt Fragment Peptides on Magnetic Nanoparticles or Synthetic Surfaces Regulate Wnt Signaling Kinetics. Int J Mol Sci. 2022;23(17):10164. Published 2022 Sep 5. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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UM206_L

Voir tous les produits spécifiques à Isoform Wnt

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

UM206_L Related Classifications

HY-P11867 Related Classifications