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Cat. No.: HY-145670

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cis,trans-Germacrone

cis,trans-Germacrone is an isomer of Germacrone (HY-N0440) and is present in the stems and leaves of Curcuma wenyujin. Germacrone exhibits a wide range of antitumor, antioxidant, and anti-inflammatory effects. Germacrone inhibits lung cancer cell proliferation and alters Akt/MDM2/p53. Germacrone also induces cell cycle arrest at the G1/S phase. Germacrone is used in lung cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 32663-51-7
Formula: C₁₅H₂₂O
Molecular Weight:218.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

cis,trans-Germacrone Chemical Structure

CAS No.: 32663-51-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Akt Isoforms :

In Vitro

cis,trans-Germacrone is isolated from the petroleum ether fraction of the 95% ethanol extract of the stems and leaves of Curcuma wenyujin and identified by NMR spectroscopy^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 32663-51-7
Molecular Weight 218.33
Formula C₁₅H₂₂O
SMILES

C/C(C)=C1C(C/C(C)=C\CC/C(C)=C/C\1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao Y, et al. Germacrone induces lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway. Molecular medicine reports. 2021 Jun;23(6):452. [Content Brief]

[2]. Wang LX, et al. [Sesquiterpenes from stems and leaves of Curcuma wenyujin]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Apr;33(7):785-8.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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