32663-51-7
Chemical Structure
cis,trans-Germacrone
- CAS No.: 32663-51-7
- Formula:C15H22O
- Molecular Weight:218.33
IUPAC Name: (S)-3-((methyl-d3)amino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide succinate
InChIKey: CAULGCQHVOVVRN-UPAULDTKSA-N
SMILES: C/C(C)=C1C(C/C(C)=C\CC/C(C)=C/C\1)=O
Biological Activity: cis,trans-Germacrone is an isomer of Germacrone (HY-N0440) and is present in the stems and leaves of Curcuma wenyujin. Germacrone exhibits a wide range of antitumor, antioxidant, and anti-inflammatory effects. Germacrone inhibits lung cancer cell proliferation and alters Akt/MDM2/p53. Germacrone also induces cell cycle arrest at the G1/S phase. Germacrone is used in lung cancer-related research[1][2].
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cis,trans-Germacrone | cis,trans-Germacrone is an isomer of Germacrone (HY-N0440) and is present in the stems and leaves of Curcuma wenyujin. Germacrone exhibits a wide range of antitumor, antioxidant, and anti-inflammatory effects. Germacrone inhibits lung cancer cell proliferation and alters Akt/MDM2/p53. Germacrone also induces cell cycle arrest at the G1/S phase. Germacrone is used in lung cancer-related research. | |||||||||||||||||||||
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References
- [1]. Zhao Y, et al. Germacrone induces lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway. Molecular medicine reports. 2021 Jun;23(6):452. [Content Brief]
- [2]. Wang LX, et al. [Sesquiterpenes from stems and leaves of Curcuma wenyujin]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2008 Apr;33(7):785-8.
