Cyclosomatostatin
Based on 1 publication(s) in Google Scholar
Cyclosomatostatin is a non-selective somatostatin receptor antagonist that blocks SSTR1-5-mediated signaling. Cyclosomatostatin decreases the ALDH+ stem cell population and sphere formation without affecting cell viability, and reduces cell proliferation. Cyclosomatostatin activates opioid receptors. Cyclosomatostatin can be used for research on arthritis and colorectal cancer.
For research use only. We do not sell to patients.
- Purity : 99.56%
- CAS No.: 84211-54-1
- Formula: C44H57N7O6
- Molecular Weight:779.97
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Cyclosomatostatin
MoreAll Opioid Receptor Isoforms
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Biological Activity
Description
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SSTR1 |
In Vitro
Cyclosomatostatin (10 μM; 48 h) significantly decreases the ALDH+ cell population, cell count, and sphere formation in HT29 and SW480 colorectal cancer cell lines without affecting cell viability[2].
Cyclo-somatostatin (0.3-3 μM; 5 min) inhibits cholinergic twitch contractions in the guinea-pig ileum with more than 50% reduction at 1 μM[4].
Cyclo-somatostatin (3-10 μM; 5 min) inhibits nerve-mediated cholinergic contractions of the rat stomach fundus strip[4].
Cyclosomatostatin (1 μM; 10 min) prevents SST-mediated hyperpolarization and reduced excitability of mouse prelimbic cortex pyramidal neurons, demonstrating that these effects are dependent on SSTRs[5].
Cyclosomatostatin (1 μM) largely does not reverse SST-mediated hyperpolarization and reduced excitability of mouse prelimbic cortex pyramidal neurons[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT29 and SW480
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Concentration:10 μM
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Incubation Time:48 h
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Result:Decreased ALDH+ cells, cell count by 50%, and sphere formation in HT29 cells without affecting cell viability.
Decreased ALDH+ cells, sphere formation, and cell count by 30% in SW480 cells without affecting cell viability.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats (adult male, 240-420 g)[1]
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Dosage:0.1 mM, 0.2 mL
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Administration:i.a.; single injection
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Result:Increased responses to noxious movements in half of the units, with a mean response of approximately 150% of control values.
The effect was transient, returning to control levels after about 30 minutes.
Chemical Information
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CAS No. 84211-54-1
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Appearance Solid
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Molecular Weight 779.97
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Formula C44H57N7O6
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Color White to off-white
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Sequence
cyclo(7-Aminoheptanoyl-Phe-dTrp-Lys-Thr(Bzl))
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Sequence Shortening
Cyclo(7-Aminoheptanoyl-FwK-Thr(Bzl))
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Clin Invest
Genomic and transcriptomic features of androgen receptor signaling inhibitor resistance in metastatic castration-resistant prostate cancer. [Abstract]2024 Aug 13;134(19):e178604. PMID: 39352383
Solvent & Solubility
In Vitro:
H2O : 5 mg/mL (6.41 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (303 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.2821 mL | 6.4105 mL | 12.8210 mL | 32.0525 mL |
| 5 mM | 0.2564 mL | 1.2821 mL | 2.5642 mL | 6.4105 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Cyclosomatostatin Related Classifications
HY-P1201 Related Classifications
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Keywords
- Cyclosomatostatin
- 84211-54-1
- Somatostatin Receptor
- Opioid Receptor
- articular afferents
- non-selective somatostatin receptor antagonist
- rat hepatocytes
- SSTR1-5-mediated signaling
- rat liver basolateral plasma membranes
- HT29 and SW480 colorectal cancer cell lines
- ALDH+ stem cell population
- pI 6.1 carboxylesterase inhibitor
- rat stomach fundus strip
- guinea-pig ileum
- Inhibitor
- inhibitor
- inhibit