CETN1 - centrin 1 Gene

Also Known as CEN1; CETN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1068

About CETN1

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:580,380-582,114 (from NCBI)

This gene has 1 transcript (splice variant), 206 orthologues and 20 paralogues.

Summary

The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during Mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. [provided by RefSeq, Jan 2015]

CETN1 Products (1)

mRNA	Protein	Name
NM_004066.3	NP_004057.1	centrin-1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20643351	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centriole	IDA IDA: Inferred from direct assay	18331714	GOA
located in centrosome	IDA IDA: Inferred from direct assay	8175926	GOA
located in centrosome	IMP IMP: Inferred from mutant phenotype	18331714	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	8175926	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CETN1 Protein Structure

EF-hand_7

EF-hand_8

0
100
172 a.a.

Protein Preferred Names	Protein Names
centrin-1	EF-hand protein

CETN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CETN1	Q12798	SGSM1	Homo sapiens	Q2NKQ1-4	Anti Tag CoIP	28514442
Intra	CETN1	Q12798	SGSM1	Homo sapiens	Q2NKQ1-4	Y2H Array	32296183
Intra	CETN1	Q12798	SGSM1	Homo sapiens	Q2NKQ1-4	Validated Y2H	25416956
Intra	CETN1	Q12798	SGSM1	Homo sapiens	Q2NKQ1-4	Validated Y2H	32296183
Intra	CETN1	Q12798	SGSM1	Homo sapiens	Q2NKQ1-4	Y2H Prey Pooling	25416956
Intra	CETN1	Q12798	SGSM1	Homo sapiens	Q2NKQ1-4	Y2H Prey Pooling	32296183
Intra	CETN1	Q12798	SGSM1	Homo sapiens	Q2NKQ1	Anti Tag CoIP	33961781
Intra	CETN1	Q12798	POC5	Homo sapiens	Q8NA72-3	Validated Y2H	32296183
Intra	CETN1	Q12798	POC5	Homo sapiens	Q8NA72-3	Anti Tag CoIP	28514442
Intra	CETN1	Q12798	POC5	Homo sapiens	Q8NA72	Y2H Array	31515488
Intra	CETN1	Q12798	POC5	Homo sapiens	Q8NA72	Anti Tag CoIP	33961781
Intra	CETN1	Q12798	POC5	Homo sapiens	Q8NA72	Validated Y2H	25416956
Intra	CETN1	Q12798	POC5	Homo sapiens	Q8NA72	Y2H Prey Pooling	25416956
Intra	CETN1	Q12798	POC5	Homo sapiens	Q8NA72	Y2H Array	25416956
Intra	CETN1	Q12798	POC5	Homo sapiens	Q8NA72	Y2H Array	29892012

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Autosomal Dominant Intellectual Developmental Disorder 40	Autosomal Dominant Non-Syndromic Intellectual Disability 40 Autosomal Dominant Mental Retardation 40 Mrd40 Mental Retardation, Autosomal Dominant 40
Night Blindness, Congenital Stationary, Autosomal Dominant 2	Congenital Stationary Night Blindness Autosomal Dominant 2 CSNBAD2 Hemeralopia Night Blindness, Congenital Stationary, Rambusch Type Rambusch Type Congenital Stationary Night Blindness Congenital Stationary Night Blindness Rambusch Type Hemeralopia Congenital Essential Blindness, Night, Stationary, Congenital, Autosomal Dominant, Type 2
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02546	CETN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CETN1	MGD	MGI:1347086
Macaca mulatta	CETN1	VGNC	VGNC:71013
Rattus norvegicus	CETN1	RGD	RGD:620246
Felis catus	CETN1	VGNC	VGNC:60799
Canis familiaris	CETN1	VGNC	VGNC:39155
Bos taurus	CETN1	VGNC	VGNC:27233
Others	CETN1	NCBI