Lofemizole
Based on 1 Customer Validation
Lofemizole is a non-steroidal anti-inflammatory agent.
For research use only. We do not sell to patients.
- Purity : 99.84%
- CAS No.: 65571-68-8
- Formula: C10H9ClN2
- Molecular Weight:192.64
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 65571-68-8
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Appearance Solid
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Molecular Weight 192.64
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Formula C10H9ClN2
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SMILES
CC1=C(C2=CC=C(Cl)C=C2)NC=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (259.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
References
[1]. Marzo A, et al. Gas-liquid chromatographic evaluation of lofemizole in biological samples for pharmacokinetic investigations Comparison of two analytical methods[J]. Journal of Chromatography B: Biomedical Sciences and Applications, 1984, 310: 51-59. [Content Brief]
[2]. Marzo A, et al., Gas--liquid chromatographic evaluation of lofemizole in biological samples for pharmacokinetic investigations. Comparison of two analytical methods. J Chromatogr. 1984 Sep 14;310(1):51-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.1910 mL | 25.9551 mL | 51.9103 mL | 129.7757 mL |
| 5 mM | 1.0382 mL | 5.1910 mL | 10.3821 mL | 25.9551 mL | |
| 10 mM | 0.5191 mL | 2.5955 mL | 5.1910 mL | 12.9776 mL | |
| 15 mM | 0.3461 mL | 1.7303 mL | 3.4607 mL | 8.6517 mL | |
| 20 mM | 0.2596 mL | 1.2978 mL | 2.5955 mL | 6.4888 mL | |
| 25 mM | 0.2076 mL | 1.0382 mL | 2.0764 mL | 5.1910 mL | |
| 30 mM | 0.1730 mL | 0.8652 mL | 1.7303 mL | 4.3259 mL | |
| 40 mM | 0.1298 mL | 0.6489 mL | 1.2978 mL | 3.2444 mL | |
| 50 mM | 0.1038 mL | 0.5191 mL | 1.0382 mL | 2.5955 mL | |
| 60 mM | 0.0865 mL | 0.4326 mL | 0.8652 mL | 2.1629 mL | |
| 80 mM | 0.0649 mL | 0.3244 mL | 0.6489 mL | 1.6222 mL | |
| 100 mM | 0.0519 mL | 0.2596 mL | 0.5191 mL | 1.2978 mL |
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