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IGF2BP3 - insulin like growth factor 2 mRNA binding protein 3 Gene

Also Known as KOC; CT98; IMP3; KOC1; IMP-3; VICKZ3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10643

About IGF2BP3

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:23,310,209-23,470,491 (from NCBI)

This gene has 18 transcripts (splice variants), 224 orthologues and 12 paralogues. Biased expression in placenta (RPKM 12.9), testis (RPKM 2.5) and 2 other tissues.

Summary

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on Other chromosomes. [provided by RefSeq, Jul 2008]

IGF2BP3 Products (1)

mRNA	Protein	Name
NM_006547.3	NP_006538.2	insulin-like growth factor 2 mRNA-binding protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables N6-methyladenosine-containing RNA reader activity	IDA IDA: Inferred from direct assay	29476152	GOA
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	20080952	GOA
enables mRNA 5'-UTR binding	IDA IDA: Inferred from direct assay	9891060	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17289661	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CRD-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	29476152	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in P-body	IDA IDA: Inferred from direct assay	29476152	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9891060	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	29476152	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGF2BP3 Protein Structure

RRM_1

KH_1

0
100
200
300
400
500
579 a.a.

Protein Preferred Names	Protein Names
insulin-like growth factor 2 mRNA-binding protein 3	IGF-II mRNA-binding protein 3

IGF2BP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IGF2BP3	O00425	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	IGF2BP3	O00425	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	IGF2BP3	O00425	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	IGF2BP3	O00425	PCBP1	Homo sapiens	Q15365	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

IGF2BP3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80724	IMP3 Antibody	WB, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P83793	IGF2BP3 Antibody (YA3490)	WB, IHC-P, FC, ELISA	Human
HY-P83793A	IGF2BP3 Antibody (YA3490)(PBS only)	WB, IHC-P, FC, ELISA	Human
HY-P85226	IMP-3 Antibody (YA4918)	WB; ICC/IF; IP; FC; IHC-P; IHC-F; IF-Tissue	Human
HY-P85583	IMP3 Antibody (YA5275)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse,

Related Diseases

Diseases	Alias
Langerhans Cell Sarcoma	Malignant Langerhans Cell Sarcoma
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Barrett Esophagus	Barrett'S Esophagus Barrett Esophagus/Esophageal Adenocarcinoma Barrett Metaplasia Barrett'S Ulcer Of Esophagus Ulcerative Esophagitis Barrett'S Esophagus With Esophagitis Barrett'S Oesophagus Barretts Syndrome Barrett Syndrome BE Peptic Ulcer Of Esophagus Adenocarcinoma Of Esophagus
Pilomyxoid Astrocytoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-174228	I3IN-002		99.35%	Unkown
HY-176471	IGF2BP3-IN-1	Inhibitor	99.05%	Unkown
HY-RS06621	IGF2BP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17518	Igf2bp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23975	Igf2bp3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IGF2BP3	VGNC	VGNC:30081
Rattus norvegicus	IGF2BP3	RGD	RGD:1306512
Canis familiaris	IGF2BP3	VGNC	VGNC:41900
Macaca mulatta	IGF2BP3	VGNC	VGNC:73453
Felis catus	IGF2BP3	VGNC	VGNC:62890
Mus musculus	IGF2BP3	MGD	MGI:1890359
Others	IGF2BP3	NCBI