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Cat. No.: HY-182673

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VT102

VT102 is a TEAD1 inhibitor with a human IC₅₀ of 391 nM. VT102 inhibits auto-palmitoylation, attenuates YAP/TEAD1 interaction, reduces expression of TEAD target genes, and inhibits YAP-mediated luciferase reporter activity. VT102 exerts weak cell growth inhibitory activity in cancer cells. VT102 can be used for the research of cancer.

For research use only. We do not sell to patients.

CAS No.: 1119382-90-9
Formula: C₂₁H₂₀BrN₅OS
Molecular Weight:470.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VT102 Chemical Structure

CAS No.: 1119382-90-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target^[1]

TEAD1

391 nM (IC₅₀)

All YAP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H2052	IC₅₀	2030 nM Compound: 40; VT102	Antiproliferative activity against human NCI-H2052 cells Antiproliferative activity against human NCI-H2052 cells	[PMID: 39047607]

In Vitro

VT102 inhibits YAP-mediated luciferase activity in a reporter assay with an IC₅₀ of 391 nM, blocks TEAD1 auto-palmitoylation, reduces TEAD target gene expression, disrupts YAP/TEAD1 interactions in NCI-H2373 cell lysate, and shows weak growth inhibition in NCI-H2052 cells with an IC₅₀ of 2030 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1119382-90-9
Molecular Weight 470.39
Formula C₂₁H₂₀BrN₅OS
SMILES

O=C(C1=CC(N=C(N(C)C)N2C3=CC=C(C=C3)Br)=C2S1)NC(C)C4=NC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lou J, et al. A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities. Eur J Med Chem. 2022;243:114684. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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VT102

All YAP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

VT102 Related Classifications

HY-182673 Related Classifications