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Cat. No.: HY-W1058089

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(E)-3-(Phenylsulfonyl)acrylic acid

(E)-3-(Phenylsulfonyl) acrylic acid is a sulfonyl acrylic acid intermediate that can be used for the preparation of NLRP3 inflammasome inhibitors.

For research use only. We do not sell to patients.

CAS No.: 711-29-5
Formula: C₉H₈O₄S
Molecular Weight:212.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(E)-3-(Phenylsulfonyl)acrylic acid Chemical Structure

CAS No.: 711-29-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

(E)-3-(Phenylsulfonyl) acrylic acid is a sulfonyl acrylic acid intermediate that can be used for the preparation of NLRP3 inflammasome inhibitors^[1].

In Vitro

(E)-3-(Phenylsulfonyl) acrylic acid (compound 4f) serves as an intermediate to prepare the NLRP3 inflammasome inhibitor compound 28a^[1] via TBTU-mediated amide condensation with 4-(2-aminoethyl) benzenesulfonamide.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 711-29-5
Molecular Weight 212.22
Formula C₉H₈O₄S
SMILES

S(/C=C/C(O)=O)(=O)(=O)C1=CC=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu J D, et al. A kind of styrene sulfone NLRP3 inflammasome inhibitor and its preparation method and application. CN111793011A, CNIPA, 2020.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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