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PACSIN2 - protein kinase C and casein kinase substrate in neurons 2 Gene

Also Known as SDPII

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11252

About PACSIN2

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:42,869,766-43,015,149 (from NCBI)

This gene has 12 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in adrenal (RPKM 24.2), colon (RPKM 24.1) and 25 other tissues.

Summary

This gene is a member of the protein kinase C and Casein Kinase substrate in neurons family. The encoded protein is involved in linking the actin Cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

PACSIN2 Products (10)

mRNA	Protein	Name
NM_001184970.3	NP_001171899.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform A
NM_001184971.1	NP_001171900.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform B
NM_001349968.1	NP_001336897.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform C
NM_001349969.2	NP_001336898.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform D
NM_001349970.2	NP_001336899.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform D
NM_001349971.2	NP_001336900.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform C
NM_001349972.1	NP_001336901.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform C
NM_001349973.1	NP_001336902.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform C
NM_001349974.2	NP_001336903.1	protein kinase C and casein kinase substrate in neurons protein 2 isoform E
NM_007229.3	NP_009160.2	protein kinase C and casein kinase substrate in neurons protein 2 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables phosphatidic acid binding	IDA IDA: Inferred from direct assay	23596323	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in caveola assembly	IMP IMP: Inferred from mutant phenotype	21610094	GOA
involved in caveolin-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	21610094	GOA
involved in plasma membrane tubulation	IDA IDA: Inferred from direct assay	23596323	GOA
involved in protein localization to endosome	IMP IMP: Inferred from mutant phenotype	23596323	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in caveola	IDA IDA: Inferred from direct assay	21610094	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	23596323	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PACSIN2 Protein Structure

FCH

SH3_9

0
100
200
300
400
486 a.a.

Protein Preferred Names	Protein Names
protein kinase C and casein kinase substrate in neurons protein 2	cytoplasmic phosphoprotein PACSIN2

PACSIN2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PACSIN2	Q9UNF0	PBX4	Homo sapiens	Q9BYU1	Y2H Array	32296183
Intra	PACSIN2	Q9UNF0	PBX4	Homo sapiens	Q9BYU1	Y2H Prey Pooling	32296183
Intra	PACSIN2	Q9UNF0	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	PACSIN2	Q9UNF0	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	PACSIN2	Q9UNF0	GSC2	Homo sapiens	O15499	Y2H Array	32296183
Intra	PACSIN2	Q9UNF0	GSC2	Homo sapiens	O15499	Y2H Prey Pooling	32296183
Intra	PACSIN2	Q9UNF0	COBL	Homo sapiens	O75128	Anti Tag CoIP	35271311
Intra	PACSIN2	Q9UNF0	COBL	Homo sapiens	O75128	Anti Tag CoIP	33961781
Intra	PACSIN2	Q9UNF0	DNM2	Homo sapiens	P50570	Anti Bait CoIP	16551695
Intra	PACSIN2	Q9UNF0	FASLG	Homo sapiens	P48023	Anti Bait CoIP	16318909
Intra	PACSIN2	Q9UNF0	FASLG	Homo sapiens	P48023	Anti Tag CoIP	16318909
Intra	PACSIN2	Q9UNF0	FASLG	Homo sapiens	P48023	Pull Down	16318909
Intra	PACSIN2	Q9UNF0	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	PACSIN2	Q9UNF0	PACSIN1	Homo sapiens	Q9BY11	Y2H Array	32296183
Intra	PACSIN2	Q9UNF0	PACSIN1	Homo sapiens	Q9BY11	Y2H Pooling	16189514
Intra	PACSIN2	Q9UNF0	PACSIN1	Homo sapiens	Q9BY11	Y2H Prey Pooling	32296183
Intra	PACSIN2	Q9UNF0	PACSIN1	Homo sapiens	Q9BY11	Anti Tag CoIP	33961781
Intra	PACSIN2	Q9UNF0	PACSIN2	Homo sapiens	Q9UNF0	Validated Y2H	32296183
Intra	PACSIN2	Q9UNF0	PACSIN2	Homo sapiens	Q9UNF0	Y2H Array	25416956
Intra	PACSIN2	Q9UNF0	PACSIN2	Homo sapiens	Q9UNF0	Y2H Array	32296183
Intra	PACSIN2	Q9UNF0	PACSIN2	Homo sapiens	Q9UNF0	Y2H Pooling	16189514
Intra	PACSIN2	Q9UNF0	PACSIN2	Homo sapiens	Q9UNF0	X-Ray Diffraction	20188097
Intra	PACSIN2	Q9UNF0	PACSIN2	Homo sapiens	Q9UNF0	Y2H Array	31515488
Intra	PACSIN2	Q9UNF0	PACSIN2	Homo sapiens	Q9UNF0	Y2H Prey Pooling	32296183
Intra	PACSIN2	Q9UNF0	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	PACSIN2	Q9UNF0	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	PACSIN2	Q9UNF0	PACSIN3	Homo sapiens	Q9UKS6	Y2H Array	32296183
Intra	PACSIN2	Q9UNF0	PACSIN3	Homo sapiens	Q9UKS6	Anti Tag CoIP	33961781
Intra	PACSIN2	Q9UNF0	PACSIN3	Homo sapiens	Q9UKS6	Y2H Prey Pooling	32296183
Intra	PACSIN2	Q9UNF0	PACSIN3	Homo sapiens	Q9UKS6	Anti Tag CoIP	35271311
Intra	PACSIN2	Q9UNF0	RIC8A	Homo sapiens	Q9NPQ8-4	Y2H Array	32296183
Intra	PACSIN2	Q9UNF0	RIC8A	Homo sapiens	Q9NPQ8-4	Y2H Prey Pooling	32296183
Intra	PACSIN2	Q9UNF0	WASL	Homo sapiens	O00401	Y2H Array	32296183
Intra	PACSIN2	Q9UNF0	WASL	Homo sapiens	O00401	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PACSIN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71184	PACSIN2 Protein, Human (HEK293, His)	Q9UNF0-1 (M1-Q486)	≥ 95%, as determined by reducing SDS-PAGE.

PACSIN2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810839	Syndapin-2 Antibody (YA10082)	WB	Human, Mouse

Related Diseases

Diseases	Alias
Thiopurines, Poor Metabolism Of, 1	Thiopurine S-Methyltransferase Deficiency Tpmt Deficiency Thiopurine Methyltransferase Deficiency Thiopurine S Methyltranferase Deficiency THPM1 Tpmtd Poor Metabolism Of Thiopurines-1 6-Mercaptopurine Sensitivity Thiopurines, Poor Metabolism Of Poor Metabolism Of Thiopurines
Microvillus Inclusion Disease	Congenital Microvillous Atrophy Intractable Diarrhea Of Infancy Congenital Familial Protracted Diarrhea With Enterocyte Brush-Border Abnormalities Davidson Disease Microvillous Inclusion Disease Congenital Microvillus Atrophy Mvid Diarrhea 2 With Microvillus Atrophy Mvd Congenital Familial Protracted Diarrhea Davidson'S Disease Familial Enteropathy, Microvillus Microvillus Atrophy, Congenital Congenital Enteropathy Familial Protracted Enteropathy Microvillous Atrophy Microvillus Atrophy With Diarrhea 2 Idi
Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive	Charcot-Marie-Tooth Disease Type 4 Charcot-Marie-Tooth Disease Type 4e Hereditary Motor And Sensory Neuropathy Cmt4e CHN1 Hypomyelinating Neuropathy, Congenital, 1 Charcot-Marie-Tooth Neuropathy Type 4e Neuropathy, Congenital Hypomyelinating, 1 Ar-Cmt1 Autosomal Recessive Demyelinating Charcot-Marie-Tooth Cmt4 Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive Hypomyelination, Severe Congenital Charcot-Marie-Tooth Disease, Type 4e Charcot-Marie-Tooth Neuropathy, Type 4e Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy Autosomal Recessive Congenital Hypomyelinating Neuropathy Congenital Amyelinating Neuropathy Congenital Hypomyelinating Neuropathy Autosomal Recessive Neuropathy, Congenital Hypomyelinating Or Amyelinating Severe Congenital Hypomyelination Hereditary Sensory Motor Neuropathy Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive Neuropathy, Hypomyelinating, Congenital, Type 1 Neuropathy, Motor And Sensory, Hereditary Congenital Hypomyelinating Neuropathy Hereditary Motor And Sensory Neuropathies Hereditary Sensorimotor Neuropathy Hmsn - [Hereditary Motor And Sensory Neuropathy] Hsmn - [Hereditary Sensory And Motor Neuropathy] Hereditary Motor And Sensory Neuropathy, Types I-Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09958	PACSIN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22015	Pacsin2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28533	Pacsin2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PACSIN2	RGD	RGD:69411
Mus musculus	PACSIN2	MGD	MGI:1345153
Canis familiaris	PACSIN2	VGNC	VGNC:44232
Bos taurus	PACSIN2	VGNC	VGNC:32543
Felis catus	PACSIN2	VGNC	VGNC:68682
Macaca mulatta	PACSIN2	VGNC	VGNC:75745
Others	PACSIN2	NCBI