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THAP12 - THAP domain containing 12 Gene

Also Known as DAP4; THAP0; PRKRIR; P52rIPK

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5612

About THAP12

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:76,349,956-76,381,132 (from NCBI)

This gene has 11 transcripts (splice variants), 295 orthologues and 18 paralogues. Ubiquitous expression in lymph node (RPKM 20.3), thyroid (RPKM 16.8) and 25 other tissues.

Summary

Predicted to enable DNA binding activity; metal ion binding activity; and protein dimerization activity. Predicted to be involved in negative regulation of cell population proliferation and signal transduction. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

THAP12 Products (1)

mRNA	Protein	Name
NM_004705.4	NP_004696.2	52 kDa repressor of the inhibitor of the protein kinase

THAP12 Protein Structure

THAP

DUF4371

Dimer_Tnp_hAT

0
200
400
600
761 a.a.

Protein Preferred Names	Protein Names
52 kDa repressor of the inhibitor of the protein kinase	58 kDa interferon-induced protein kinase-interacting protein

THAP12 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	THAP12	O43422	KIAA1958	Homo sapiens	Q8N8K9	Y2H Array	32296183
Intra	THAP12	O43422	KIAA1958	Homo sapiens	Q8N8K9	Y2H Prey Pooling	32296183
Intra	THAP12	O43422	KIAA1958	Homo sapiens	Q8N8K9	Validated Y2H	32296183
Intra	THAP12	O43422	ZNF526	Homo sapiens	Q8TF50	Validated Y2H	32296183
Intra	THAP12	O43422	ZNF526	Homo sapiens	Q8TF50	Y2H Array	32296183
Intra	THAP12	O43422	ZNF526	Homo sapiens	Q8TF50	Y2H Prey Pooling	32296183
Intra	THAP12	O43422	ZNF526	Homo sapiens	Q8TF50	Anti Tag CoIP	33961781
Intra	THAP12	O43422	TACC1	Homo sapiens	O75410-7	Y2H Array	32296183
Intra	THAP12	O43422	TACC1	Homo sapiens	O75410-7	Y2H Prey Pooling	32296183
Intra	THAP12	O43422	TACC1	Homo sapiens	O75410-7	Validated Y2H	32296183
Intra	THAP12	O43422	ZNF574	Homo sapiens	Q6ZN55	Anti Tag CoIP	33961781
Intra	THAP12	O43422	TACC1	Homo sapiens	O75410	Y2H Prey Pooling	25416956
Intra	THAP12	O43422	TACC1	Homo sapiens	O75410	Validated Y2H	25416956
Intra	THAP12	O43422	SELENBP1	Homo sapiens	Q13228	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 58	RP58 Retinitis Pigmentosa, Type 58
Schimmelpenning-Feuerstein-Mims Syndrome	Nevus Sebaceus Of Jadassohn Organoid Nevus Phakomatosis Linear Nevus Sebaceous Syndrome Sfm Syndrome Jadassohn Nevus Phakomatosis Jnp Schimmelpenning Syndrome Solomon Syndrome SFM Linear Sebaceous Nevus Syndrome Schimmelpenning-Feuerstein-Mims Syndrome, Somatic Mosaic Nevus Sebaceus Syndrome Organoid Nevus Syndrome Schimmelpenning Feuerstein Mims Syndrome Sebaceous Nevus Syndrome, Linear Epidermal Nevus Syndrome, Formerly Sebaceous Nevus Syndrome Linear Linear Nevus Sebaceus Syndrome Epidermal Nevus Syndrome Ss Nevus Sebaceous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS14472	THAP12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	THAP12	RGD	RGD:1309679
Mus musculus	THAP12	MGD	MGI:1920231
Bos taurus	THAP12	VGNC	VGNC:35820
Felis catus	THAP12	VGNC	VGNC:81938
Macaca mulatta	THAP12	VGNC	VGNC:107650
Canis familiaris	THAP12	VGNC	VGNC:47326
Others	THAP12	NCBI