EM-163
Based on 1 Customer Validation
EM-163 is a summative BB-Loop analog. EM-163 can alleviate inflammation and prevent death from toxic shock by targeting the TIR domain of MyD88. EM-163 can be used in the study of SEB poisoning (SEB: Staphylococcal enterotoxin B).
For research use only. We do not sell to patients.
- Purity : 95.0%
- CAS No.: 1206480-93-4
- Formula: C44H60IN5O4
- Molecular Weight:849.88
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
EM-163 (50-100 μg/mL) can target the TIR domain, binding to the protein of the TIR domain and inhibit the interaction of the TIR-TIR domain [1].
EM-163 (10-500 μM; 30 min) inhibits the production of TNF-α, IFN-γ, IL-2 and IL-1b induced by SEB (200 ng/mL) in human mononuclear cells (MNS) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SEB-induced BALB/c mice model [1]
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Dosage:0.21 mg/mouse, 0.42 mg/mouse, 0.86 mg/mouse
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Administration:Intraperitoneal injection (i.p.); Single dose. Before SEB treatment (0.5 μg/mouse, 5 μg/mouse; i.p.; single dose) and LPS treatment.
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Result:Delayed mouse death at a dose of 0.21 mg/mouse, and protected mice from death at either dose of 0.42 mg/mouse or 0.86 mg/mouse.
Delayed mouse death even at high doses of SEB (5 μg).
Chemical Information
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CAS No. 1206480-93-4
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Appearance Solid
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Molecular Weight 849.88
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Formula C44H60IN5O4
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Color Brown to dark brown
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SMILES
O=C(N1CCCC1)[C@H](C(C)C)N(CCCC2=CC=CC=C2)C(C3=C[N+](C)=C(C=C3)C(N(CCCC4=CC=CC=C4)[C@@H](C(C)C)C(N5CCCC5)=O)=O)=O.[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EM-163 Related Classifications
HY-163035 Related Classifications
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