CA1001
CA1001 is a small-molecule ZNF74 inhibitor and a peripherally restricted κ/δ dual opioid receptor agonist. CA1001 exhibits potent antitumor activity both in vitro and in vivo. CA1001, in combination with immune checkpoint inhibitors, significantly enhances tumor regression. CA1001 activates peripherally restricted κ/δ dual opioid receptors and exerts analgesic effects under conditions of inflammatory pain, neuropathic pain, and mechanical hyperalgesia. CA1001 can be used in research related to melanoma, mechanical hyperalgesia, neuropathic pain, and inflammatory arthritis pain.
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Human
CA1001 exhibits potent anti-tumor activity in melanoma cell lines[1].
CA1001 exerts a synergistic effect when combined with immune checkpoint inhibitors, significantly enhancing tumor regression in melanoma cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CA1001 (1-10 mg/kg, i.p., single administration) significantly reverses mechanical hyperalgesia at 10 mg/kg at 2 h and 4 h[2].
CA1001 (1-10 mg/kg, i.p., single administration) significantly increases paw withdrawal threshold and reverses Complete Freund's adjuvant (CFA) (HY-153808)-induced mechanical hyperalgesia[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat[2]
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Dosage:1 mg/kg, 5 mg/kg, 10 mg/kg
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Administration:i.p., once
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Result:Significantly reversed mechanical hyperalgesia at 10 mg/kg at 2 h and 4 h.
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Animal Model:Rat[2]
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Dosage:1 mg/kg, 5 mg/kg, 10 mg/k
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Administration:i.p., once
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Result:Significantly increased paw withdrawal threshold and reverses Complete Freund's adjuvant (CFA) (HY-153808)-induced mechanical hyperalgesia.
P07359
CD42b/GP1BA
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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SMILES
[CA1001]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CA1001 Related Classifications
HY-P992012 Related Classifications
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