DS17701585
DS17701585 (Compound 11) is a highly selective, orally active EP300 and CBP inhibitor with IC50 values of 0.040, 0.15, 0.45 and 0.70 µM against CBP, EP300, H3K27 and SOX2. DS17701585 can be used for cancer research.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2983027-66-1
- Fòrmula: C24H26N4O5S
- Peso molecular:482.55
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Protocolo
- Pureza y Documentación
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
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H3K27 0.45 μM (IC50) |
SOX2 0.70 μM (IC50) |
EP300 0.04 μM (IC50) |
CBP 0.15 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| LK-2 | IC50 |
0.7 μM
Compound: 11; DS17701585
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Inhibition of SOX2 mRNA expression in human LK2 cells incubated for 6 hrs by RT-qPCR analysis
Inhibition of SOX2 mRNA expression in human LK2 cells incubated for 6 hrs by RT-qPCR analysis
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[PMID: 35413416] |
Chemical Information
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No. CAS 2983027-66-1
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Peso molecular 482.55
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Fòrmula C24H26N4O5S
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SMILES
O=C([C@@H](C1)N(C(C2(C3=CC=C(OC)C=C3)CCCC2)=O)CS1(=O)=O)NC4=CC=CC5=C4C=NN5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocolo
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DS17701585 Related Classifications
HY-143443 Related Classifications
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