(±)-Eudesmin
(±)-Eudesmin ((±)-Eudesmine) is a natural compound found in Fragaria nubicola with in vitro anti-inflammatory activity. (±)-Eudesmin inhibits NO production in LPS-activated macrophages; suppresses myeloperoxidase-dependent ROS production in zymosan-activated phagocytes; and inhibits superoxide anion production in PMA-activated macrophages. (±)-Eudesmin can be used for the research of inflammation-related diseases.
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- No. CAS: 25305-05-9
- Fòrmula: C22H26O6
- Peso molecular:386.44
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Descripciòn
In Vitro
(±)-Eudesmin (compound 4) moderately inhibits nitric oxide production in LPS-activated J774.2 mouse macrophages, with 29.3% inhibition at 25 µg/mL[1].
(±)-Eudesmin (1-100 µg/mL; 15 min) potently inhibits myeloperoxidase-dependent ROS production in zymosan-activated human peripheral whole blood cells, with an IC50 of 2.3 µg/mL[1].
(±)-Eudesmin (0.5-25 µg/mL; 48 h) is non-cytotoxic to NIH 3T3 mouse fibroblasts, with an IC50 value greater than 25 µg/mL and no toxicity observed at concentrations up to 50 µg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NIH 3T3 mouse fibroblast cells
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Concentration:0.5, 5, 25 µg/mL
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Incubation Time:48 h
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Result:Showed no cytotoxicity toward NIH 3T3 mouse fibroblasts at concentrations up to 50 µg/mL.
Chemical Information
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No. CAS 25305-05-9
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Appearance Solid
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Peso molecular 386.44
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Fòrmula C22H26O6
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Color White to off-white
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SMILES
COC1=CC(C2OCC3C(C4=CC=C(C(OC)=C4)OC)OCC23)=CC=C1OC
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Synonyms
(±)-Eudesmine
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
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Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(±)-Eudesmin Related Classifications
HY-N2180A Related Classifications
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