MPP3 - MAGUK p55 scaffold protein 3 Gene

Also Known as DLG3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4356

About MPP3

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:43,800,811-43,833,146 (from NCBI)

This gene has 9 transcripts (splice variants), 275 orthologues and 7 paralogues. Broad expression in heart (RPKM 3.1), lung (RPKM 2.5) and 23 other tissues.

Summary

This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the Cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (Src homology 3) motif, found in several Other proteins that associate with the Cytoskeleton and are suspected to play important roles in signal transduction. Alternatively spliced transcript variants have been identified. One transcript variant is experimentally supported, but it doesn't encode a protein. [provided by RefSeq, Jul 2008]

MPP3 Products (3)

mRNA	Protein	Name
NM_001330233.2	NP_001317162.1	MAGUK p55 subfamily member 3 isoform 2
NM_001353080.2	NP_001340009.1	MAGUK p55 subfamily member 3 isoform 3
NM_001932.6	NP_001923.2	MAGUK p55 subfamily member 3 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16519681	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	24503895	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPP3 Protein Structure

L27

PDZ

SH3_2

Guanylate_kin

0
100
200
300
400
500
585 a.a.

Protein Preferred Names	Protein Names
MAGUK p55 subfamily member 3	discs, large homolog 3

MPP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	MPP3	Q13368	LIN7C	Homo sapiens	Q9NUP9	Y2H Array	32296183
Intra	MPP3	Q13368	LIN7C	Homo sapiens	Q9NUP9	Validated Y2H	32296183
Intra	MPP3	Q13368	LIN7C	Homo sapiens	Q9NUP9	Y2H Prey Pooling	32296183
Intra	MPP3	Q13368	PKNOX1	Homo sapiens	P55347	Y2H Prey Pooling	32296183
Intra	MPP3	Q13368	PKNOX1	Homo sapiens	P55347	Y2H Array	32296183
Intra	MPP3	Q13368	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	MPP3	Q13368	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	MPP3	Q13368	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	MPP3	Q13368	LIN7B	Homo sapiens	Q9HAP6	Validated Y2H	32296183
Intra	MPP3	Q13368	LIN7B	Homo sapiens	Q9HAP6	Y2H Array	32296183
Intra	MPP3	Q13368	LIN7B	Homo sapiens	Q9HAP6	Y2H Prey Pooling	32296183
Intra	MPP3	Q13368	BTBD1	Homo sapiens	Q9H0C5	Y2H Prey Pooling	32296183
Intra	MPP3	Q13368	BTBD1	Homo sapiens	Q9H0C5	Validated Y2H	32296183
Intra	MPP3	Q13368	BTBD1	Homo sapiens	Q9H0C5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Non-Syndromic X-Linked Intellectual Disability 90	Mrx90
Chromosome 3q29 Deletion Syndrome	Chromosome 3q29 Microdeletion Syndrome 3q29 Microdeletion Syndrome 3q Subtelomere Deletion Syndrome 3q29 Recurrent Deletion 3qter Deletion 3q29 Deletion Syndrome Monosomy 3q29 Microdeletion 3q29 Syndrome Del(3)(Q29) Monosomy 3qter 3q29 Deletion Del3q29
Immunodeficiency 46	Tfrc-Related Combined Immunodeficiency IMD46 Cid Due To Tfrc Deficiency Combined Immunodeficiency Due To Tfrc Deficiency
Late-Onset Retinal Degeneration	LORD Retinal Degeneration, Late-Onset, Autosomal Dominant Autosomal Dominant Late-Onset Retinal Degeneration Pigmentary Retinopathy Retinal Degeneration, Late-Onset Retinitis Pigmentosa
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS08624	MPP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MPP3	VGNC	VGNC:74921
Bos taurus	MPP3	VGNC	VGNC:55850
Rattus norvegicus	MPP3	RGD	RGD:620015
Mus musculus	MPP3	MGD	MGI:1328354
Felis catus	MPP3	VGNC	VGNC:97515
Canis familiaris	MPP3	VGNC	VGNC:43344
Others	MPP3	NCBI