Melredableukin alfa
Based on 1 Customer Validation
Melredableukin alfa (RG7835) is a bivalent conjugate composed of a human IL-2 mutant (T3A, N88D, C125A) and human IgG1. Melredableukin alfa exhibits enhanced Treg cell selectivity in cynomolgus monkey and humanized mouse models. Melredableukin alfa can be used in research related to ulcerative colitis and autoimmune hepatitis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 96.22%
- No. CAS: 2056881-92-4
- Peso molecular:175.32 kDa
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
Isotype
Human IgG1 kappa
Recommend Isotype Controls
IC50 & Target
[1]|
IL-2 |
In Vivo
Melredableukin alfa exhibits enhanced Treg cell selectivity in cynomolgus monkey and humanized mouse models[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
Aplicación
ELISA, FACS, Functional assay
Chemical Information
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No. CAS 2056881-92-4
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Appearance Liquid
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Peso molecular 175.32 kDa
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Color Colorless to light yellow
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SMILES
[Melredableukin alfa]
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Synonyms
RG7835; RO7049665
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (257 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
[1]. Lykhopiy V, et al. IL-2 immunotherapy for targeting regulatory T cells in autoimmunity". Genes Immun. 2023 Oct;24(5):248-262. [Content Brief]
[2]. Efe O, et al. A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models. J Clin Invest. 2024;134(5):e173107. Published 2024 Mar 1. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Melredableukin alfa Related Classifications
HY-P99728 Related Classifications
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Keywords
- Melredableukin alfa
- 2056881-92-4
- RG7835
- RO7049665
- RG 7835
- RG-7835
- RO7049665
- RO 7049665
- RO-7049665
- Interleukin Related
- cynomolgus monkeys
- CD4-positive regulatory T cells
- CD56bright NK cells
- humanized mouse models
- CD8-positive regulatory T cells
- ulcerative colitis
- FOXP3-positive regulatory T cells
- interleukin-2 receptor alpha (CD25)
- immunosuppressive agent
- Treg
- Inhibitor
- inhibitor
- inhibit