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Referencia número: HY-183912

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PY-4Car2

PY-4Car2 is a Camptothecin (HY-16560) derivative and a topoisomerase I inhibitor. PY-4Car2 functions as a warhead conjugated via a cleavable linker to the bispecific ADC TJ101. PY-4Car2 can be used as an ADC payload for the research of cancers_.

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No. CAS: 3054643-04-5
Fòrmula: C₂₉H₃₀FN₃O₇
Peso molecular:551.56

Almacenamiento:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

PY-4Car2 Chemical Structure

No. CAS: 3054643-04-5

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- In Vitro
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Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Topoisomerase :

Ver todos los productos específicos de isoformas ADC Payloads :

In Vitro

PY-4CAR2, when delivered via the bispecific dual-payload ADC TJ102 (co-formulated with PE-E2K), contributes to robust, selective cytotoxicity in ovarian and kidney cancer cell lines^[1].
PY-4Car2, as the warhead of bispecific ADC TJ101, drives synergistic cytotoxicity in EGFR- and B7-H3-coexpressing solid cancer cell lines, with activity dependent on target antigen binding^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 3054643-04-5
Appearance Solid
Peso molecular 551.56
Fòrmula C₂₉H₃₀FN₃O₇
Color White to light yellow
SMILES

OCCCCOC(N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Yangxin Zhang, et al. Abstract LB021: TJ102: A promising bispecific dual-payload ADC targeting CDH6 and folate receptor alpha (FRα) for the treatment of ovarian and kidney cancers. Cancer Res (2025) 85 (8_Supplement_2): LB021.

[2]. Li Qi, et al. Abstract 2955: Preclinical development of TJ101, a potent bispecific ADC targeting EGFR and B7-H3 for the treatment of solid cancers. Cancer Res (2025) 85 (8_Supplement_1): 2955.

Calculators

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Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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PY-4Car2

Ver todos los productos específicos de isoformas Topoisomerase

Ver todos los productos específicos de isoformas ADC Payloads

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

PY-4Car2 Related Classifications

HY-183912 Related Classifications