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Referencia número: HY-117476

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Sapelin B

Sapelin B is a naturally occurring tirucallane-type triterpenoid that exhibits in vivo antitumor activity in a mouse model of P-388 lymphocytic leukemia. Sapelin B can be used in leukemia-related research.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 26790-94-3
Fòrmula: C₃₀H₅₀O₄
Peso molecular:474.72

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Sapelin B Chemical Structure

No. CAS: 26790-94-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
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Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Endogenous Metabolite :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	10 μM Compound: 26	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]
A549	IC₅₀	>10 μM Compound: 26	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]
MCF7	IC₅₀	>10 μM Compound: 26	Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]
MCF7	IC₅₀	10 μM Compound: 26	Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]
MKN-28	IC₅₀	>10 μM Compound: 26	Cytotoxicity against human MKN28 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human MKN28 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]
MKN-28	IC₅₀	10 μM Compound: 26	Cytotoxicity against human MKN28 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay Cytotoxicity against human MKN28 cells assessed as inhibition of cell proliferation after 48 hrs by MTT assay	[PMID: 27494664]

In Vivo

Sapelin B (1.25-10.0 mg/kg) exhibits in vivo antitumor activity in the P-388 lymphocytic leukemia mouse model, with T/C survival ratios ≥ 125% across all tested doses^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 26790-94-3
Peso molecular 474.72
Fòrmula C₃₀H₅₀O₄
SMILES

CC1([C@@H](CC[C@@]2([C@]3(CC[C@]4([C@](CC[C@@]4(C3=CC[C@@]12[H])C)([H])[C@@]5([H])COC(C)(C)[C@@H](O)[C@H](O)C5)C)[H])C)O)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Wu W B, et al. New triterpenoids with protein tyrosine phosphatase 1B inhibition from Cedrela odorata. Journal of Asian Natural Products Research, 2014, 16(7): 709-716.

[2]. Jolad SD, et al. Cytotoxic agents from Bursera klugii (Burseraceae) I: isolation of sapelins A and B. Journal of pharmaceutical sciences. 1977 Jun;66(6):889-90. [Content Brief]

Calculators

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Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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