STAT3-IN-20
Based on 1 Customer Validation
STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC50: 0.65 μM). STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC50: 2.97 μM and 3.26 μM respectively). STAT3-IN-20 induces cell cycle arrest and apoptosis.
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- Pureza : 99.83%
- No. CAS: 2768427-54-7
- Fòrmula: C30H27F4N7S
- Peso molecular:593.64
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
0.65 μM (STAT3)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
2.97 μM
Compound: 40
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Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
Antiproliferative activity against human DU-145 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
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[PMID: 37594012] |
| HCT-116 | IC50 |
2.19 μM
Compound: 40
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
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[PMID: 37594012] |
| HepG2 | IC50 |
1.45 μM
Compound: 40
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Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
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[PMID: 37594012] |
| MDA-MB-231 | IC50 |
3.26 μM
Compound: 40
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Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
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[PMID: 37594012] |
| PANC-1 | IC50 |
2.43 μM
Compound: 40
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Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
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[PMID: 37594012] |
| PBMC | IC50 |
16.3 μM
Compound: 40
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Antiproliferative activity against human PBMC cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
Antiproliferative activity against human PBMC cells assessed as inhibition of cell growth measured after 96 hrs by MTT assay
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[PMID: 37594012] |
Chemical Information
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No. CAS 2768427-54-7
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Appearance Solid
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Peso molecular 593.64
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Fòrmula C30H27F4N7S
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Color Light yellow to yellow
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SMILES
FC1=CC=C(C2=NC3=CC(NC4=NN=C(S4)C5=CC=C(C=C5)C(F)(F)F)=C(C=C3N2C6CC6)N7CCN(CC7)C)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 100 mg/mL (168.45 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6845 mL | 8.4226 mL | 16.8452 mL | 42.1131 mL |
| 5 mM | 0.3369 mL | 1.6845 mL | 3.3690 mL | 8.4226 mL | |
| 10 mM | 0.1685 mL | 0.8423 mL | 1.6845 mL | 4.2113 mL | |
| 15 mM | 0.1123 mL | 0.5615 mL | 1.1230 mL | 2.8075 mL | |
| 20 mM | 0.0842 mL | 0.4211 mL | 0.8423 mL | 2.1057 mL | |
| 25 mM | 0.0674 mL | 0.3369 mL | 0.6738 mL | 1.6845 mL | |
| 30 mM | 0.0562 mL | 0.2808 mL | 0.5615 mL | 1.4038 mL | |
| 40 mM | 0.0421 mL | 0.2106 mL | 0.4211 mL | 1.0528 mL | |
| 50 mM | 0.0337 mL | 0.1685 mL | 0.3369 mL | 0.8423 mL | |
| 60 mM | 0.0281 mL | 0.1404 mL | 0.2808 mL | 0.7019 mL | |
| 80 mM | 0.0211 mL | 0.1053 mL | 0.2106 mL | 0.5264 mL | |
| 100 mM | 0.0168 mL | 0.0842 mL | 0.1685 mL | 0.4211 mL |
STAT3-IN-20 Related Classifications
HY-155982 Related Classifications
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