Dnajc3 - DnaJ heat shock protein family (Hsp40) member C3 Gene

Also Known as p58; mp58; Prkri; p58IPK; Dnajc3a; Dnajc3b

Species: Mus musculus

Gene Type: protein coding

Gene ID: 100037258

Summary

Enables several functions, including chaperone binding activity; misfolded protein binding activity; and protein kinase inhibitor activity. Involved in cellular response to cold; proteolysis involved in cellular protein catabolic process; and regulation of translational initiation. Located in cytosol and endoplasmic reticulum lumen. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human DNAJC3 (DnaJ heat shock protein family (HSP40) member C3). [provided by Alliance of Genome Resources, Apr 2022]

Dnajc3 Products (1)

mRNA	Protein	Name
NM_008929.4	NP_032955.2	dnaJ homolog subfamily C member 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables misfolded protein binding	IDA IDA: Inferred from direct assay	18923430	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18923430	MGI
enables protein kinase binding	IDA IDA: Inferred from direct assay	25329545	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	25329545	MGI
enables protein kinase inhibitor activity	IDA IDA: Inferred from direct assay	25329545	MGI
enables protein-folding chaperone binding	IDA IDA: Inferred from direct assay	16923392	MGI
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	18923430	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to cold	IDA IDA: Inferred from direct assay	25329545	MGI
involved in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	IDA IDA: Inferred from direct assay	25329545	MGI
involved in positive regulation of translation initiation in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	25329545	MGI
involved in proteolysis involved in protein catabolic process	IDA IDA: Inferred from direct assay	18923430	MGI
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	16923392	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8666242	MGI
located in cytosol	IDA IDA: Inferred from direct assay	25329545	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	25329545	MGI
located in endoplasmic reticulum lumen	IDA IDA: Inferred from direct assay	18923430	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
dnaJ homolog subfamily C member 3	DnaJ (Hsp40) homolog, subfamily C, member 3 DnaJ (Hsp40) homolog, subfamily C, member 3A DnaJ (Hsp40) homolog, subfamily C, member 3B interferon-induced, double-stranded RNA-activated protein kinase inhibitor protein kinase inhibitor of 58 kDa protei

Dnajc3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Dnajc3	Q91YW3	HSPA5	Homo sapiens	P11021	Anti Tag CoIP	18923430
Cross	Dnajc3	Q91YW3	HSPA5	Homo sapiens	P11021	Pull Down	18923430

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03884	DNAJC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21846	Dnajc3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28362	Dnajc3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dnajc3	NCBI	NCBI:5611