Abo - ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Gene

Also Known as Abo2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 100301568

Summary

Enables alpha-1,3-galactosyltransferase activity and glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity. Involved in several processes, including cellular oligosaccharide metabolic process; response to nematode; and response to retinoic acid. Located in Golgi apparatus and cytoplasmic vesicle. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; gallbladder carcinoma; leukemia (multiple); lung disease (multiple); and severe acute respiratory syndrome. Orthologous to human ABO (ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Abo Products (1)

mRNA Protein Name
NM_001160263.2 NP_001153735.1 histo-blood group ABO system transferase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables alpha-1,3-galactosyltransferase activity IDA
IDA: Inferred from direct assay
12626403 RGD
enables glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity IDA
IDA: Inferred from direct assay
11842091 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12499407 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12499407 RGD
involved in response to nematode IEP
IEP: Inferred from expression pattern
11842091 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
15042712 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histo-blood group ABO system transferase 2

  • ABO blood group (alpha 1-3-N-acetylgalactosaminyltransferase, alpha 1-3-galactosyltransferase)

  • ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase

  • ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase

  • trans

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991921 TNX-1500 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115635 ABO hydrochloride Modulator 98.70% Unkown
HY-E70051 alpha-1,3-N-Acetylgalactosaminyltransferase (Pm1138) / Unkown
HY-RS00109 ABO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17181 Abo Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23632 Abo Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W145682 Blood group H disaccharide / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abo NCBI NCBI:28