Slc15a4 - solute carrier family 15, member 4 Gene

Also Known as PHT1; PTR4; C130069N12Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 100561

Summary

Enables L-histidine transmembrane transporter activity and peptide:proton symporter activity. Involved in several processes, including L-histidine transmembrane export from vacuole; positive regulation of pattern recognition receptor signaling pathway; and regulation of isotype switching to IgG isotypes. Located in early endosome membrane and lysosomal membrane. Is integral component of endosome membrane and integral component of lysosomal membrane. Is expressed in embryo. Orthologous to human SLC15A4 (solute carrier family 15 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc15a4 Products (1)

mRNA	Protein	Name
NM_133895.1	NP_598656.1	solute carrier family 15 member 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables L-histidine transmembrane transporter activity	IDA IDA: Inferred from direct assay	21277849	MGI
enables L-histidine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	29784761	MGI
enables peptide:proton symporter activity	IMP IMP: Inferred from mutant phenotype	29784761	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in L-histidine transmembrane export from vacuole	IMP IMP: Inferred from mutant phenotype	27845049	MGI
involved in mast cell homeostasis	IMP IMP: Inferred from mutant phenotype	29155995	MGI
involved in peptidoglycan transport	IDA IDA: Inferred from direct assay	24695226	MGI
involved in peptidoglycan transport	IMP IMP: Inferred from mutant phenotype	29784761	MGI
involved in positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	IMP IMP: Inferred from mutant phenotype	19570976	MGI
involved in positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA IDA: Inferred from direct assay	24695226	MGI
involved in positive regulation of toll-like receptor 7 signaling pathway	IMP IMP: Inferred from mutant phenotype	21045126	MGI
involved in positive regulation of toll-like receptor 9 signaling pathway	IMP IMP: Inferred from mutant phenotype	21045126	MGI
involved in regulation of isotype switching to IgG isotypes	IMP IMP: Inferred from mutant phenotype	25310967	MGI
involved in regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	29784761	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in early endosome membrane	IDA IDA: Inferred from direct assay	19570976	MGI
located in endosome membrane	IDA IDA: Inferred from direct assay	24695226	MGI
located in lysosomal membrane	IDA IDA: Inferred from direct assay	21277849	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
solute carrier family 15 member 4	peptide transporter 4 peptide-histidine transporter 4 peptide/histidine transporter 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149652	IRF5-IN-1	Inhibitor	99.91%	Unkown
HY-155863	AJ2-71		99.80%	Unkown
HY-RS13015	SLC15A4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21255	Slc15a4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27774	Slc15a4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc15a4	NCBI	NCBI:121260