SLC15A4 - solute carrier family 15 member 4 Gene

Also Known as PHT1; PTR4; FP12591

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 121260

About SLC15A4

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:128,793,194-128,823,958 (from NCBI)

This gene has 8 transcripts (splice variants), 204 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 17.6), testis (RPKM 10.0) and 25 other tissues.

Summary

Enables L-histidine transmembrane transporter activity; peptide transmembrane transporter activity; and peptidoglycan transmembrane transporter activity. Involved in several processes, including dipeptide import across plasma membrane; peptidoglycan transport; and positive regulation of Toll-like Receptor signaling pathway. Located in endolysosome membrane. Is integral component of lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC15A4 Products (1)

mRNA Protein Name
NM_145648.4 NP_663623.1 solute carrier family 15 member 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-histidine transmembrane transporter activity IDA
IDA: Inferred from direct assay
25238095 GOA
enables dipeptide transmembrane transporter activity IDA
IDA: Inferred from direct assay
29224352 GOA
enables peptide:proton symporter activity IDA
IDA: Inferred from direct assay
25238095 GOA
enables peptidoglycan transmembrane transporter activity IDA
IDA: Inferred from direct assay
25238095 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
24695226 GOA
Biological Process GO Annotation Evidence References Source
involved in dipeptide import across plasma membrane IDA
IDA: Inferred from direct assay
29224352 GOA
involved in peptidoglycan transport IDA
IDA: Inferred from direct assay
25238095 GOA
involved in positive regulation of innate immune response IDA
IDA: Inferred from direct assay
32433612 GOA
involved in positive regulation of toll-like receptor 7 signaling pathway IMP
IMP: Inferred from mutant phenotype
25238095 GOA
involved in positive regulation of toll-like receptor 8 signaling pathway IMP
IMP: Inferred from mutant phenotype
32433612 GOA
involved in positive regulation of toll-like receptor 9 signaling pathway IMP
IMP: Inferred from mutant phenotype
25238095 GOA
Cellular Component GO Annotation Evidence References Source
located in endolysosome membrane IDA
IDA: Inferred from direct assay
32433612 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
25238095 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC15A4 Protein Structure

PTR2

PTR2: POT family (104 - 495)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 577 a.a.
Protein Preferred Names Protein Names

solute carrier family 15 member 4

  • hPHT1

SLC15A4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC15A4 Q8N697 TASL Homo sapiens Q9HAI6
Anti Bait CoIP
32433612
Intra
SLC15A4 Q8N697 TASL Homo sapiens Q9HAI6
Anti Tag CoIP
32433612
Intra
SLC15A4 Q8N697 TASL Homo sapiens Q9HAI6
Confocal
32433612
Intra
SLC15A4 Q8N697 TASL Homo sapiens Q9HAI6
TAP
32433612
Intra
SLC15A4 Q8N697 NOD2 Homo sapiens Q9HC29
Anti Tag CoIP
24695226
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypotrichosis 4

  • HYPT4

  • Marie Unna Hereditary Hypotrichosis 1

  • Muhh1

  • Hypotrichosis, Marie Unna Type, 1

  • Hypotrichosis Marie Unna 1

  • Marie Unna Hereditary Hypotrichosis Type 1

  • Hypotrichosis, Hereditary, Marie Unna Type, 1

  • Hypotrichosis, Type 4
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149652 IRF5-IN-1 Inhibitor 99.91% Unkown
HY-155863 AJ2-71 99.80% Unkown
HY-RS13015 SLC15A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21255 Slc15a4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27774 Slc15a4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SLC15A4 VGNC VGNC:65203
Macaca mulatta SLC15A4 VGNC VGNC:77557
Rattus norvegicus SLC15A4 RGD RGD:708469
Mus musculus SLC15A4 MGD MGI:2140796
Canis familiaris SLC15A4 VGNC VGNC:52967
Bos taurus SLC15A4 VGNC VGNC:34681
Others SLC15A4 NCBI