Numa1 - nuclear mitotic apparatus protein 1 Gene

Also Known as NuMA; 6720401E04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 101706

Summary

Predicted to enable several functions, including disordered domain specific binding activity; dynein complex binding activity; and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; positive regulation of BMP signaling pathway; and positive regulation of keratinocyte differentiation. Acts upstream of or within lung epithelial cell differentiation. Located in several cellular components, including lateral cell cortex; mitotic spindle pole; and nuclear matrix. Is expressed in lung epithelium; midbrain ventricular layer; olfactory lobe; pigmented retinal epithelium; and telencephalon ventricular layer. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human NUMA1 (nuclear mitotic apparatus protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Numa1 Products (11)

mRNA Protein Name
NM_001403544.1 NP_001390473.1 nuclear mitotic apparatus protein 1 isoform a
NM_001403545.1 NP_001390474.1 nuclear mitotic apparatus protein 1 isoform a
NM_001403546.1 NP_001390475.1 nuclear mitotic apparatus protein 1 isoform a
NM_001403547.1 NP_001390476.1 nuclear mitotic apparatus protein 1 isoform a
NM_001403548.1 NP_001390477.1 nuclear mitotic apparatus protein 1 isoform a
NM_001403549.1 NP_001390478.1 nuclear mitotic apparatus protein 1 isoform a
NM_001403550.1 NP_001390479.1 nuclear mitotic apparatus protein 1 isoform a
NM_001403551.1 NP_001390480.1 nuclear mitotic apparatus protein 1 isoform b
NM_001403552.1 NP_001390481.1 nuclear mitotic apparatus protein 1 isoform c
NM_001403553.1 NP_001390482.1 nuclear mitotic apparatus protein 1 isoform d
NM_133947.4 NP_598708.3 nuclear mitotic apparatus protein 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25936915 MGI
Biological Process GO Annotation Evidence References Source
involved in establishment of mitotic spindle orientation IMP
IMP: Inferred from mutant phenotype
26765568 MGI
involved in positive regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
26765568 MGI
involved in positive regulation of hair follicle development IMP
IMP: Inferred from mutant phenotype
26765568 MGI
involved in positive regulation of keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
26765568 MGI
Cellular Component GO Annotation Evidence References Source
located in cell cortex region IDA
IDA: Inferred from direct assay
26765568 MGI
located in lateral cell cortex IMP
IMP: Inferred from mutant phenotype
26766442 MGI
located in mitotic spindle pole IDA
IDA: Inferred from direct assay
26765568 MGI
located in nuclear matrix IDA
IDA: Inferred from direct assay
11092755 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear mitotic apparatus protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09680 NUMA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21675 Numa1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28193 Numa1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Numa1 NCBI NCBI:4926