TRIB1 - tribbles pseudokinase 1 Gene

Also Known as C8FW; GIG2; TRB1; GIG-2; SKIP1; TRB-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10221

About TRIB1

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:125,430,358-125,438,403 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 87.7), liver (RPKM 53.0) and 20 other tissues.

Summary

Enables mitogen-activated protein kinase kinase binding activity and protein kinase inhibitor activity. Involved in several processes, including JNK cascade; negative regulation of lipopolysaccharide-mediated signaling pathway; and regulation of protein kinase activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TRIB1 Products (2)

mRNA Protein Name
NM_001282985.2 NP_001269914.1 tribbles homolog 1 isoform 2
NM_025195.4 NP_079471.1 tribbles homolog 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
17724128 GOA
enables mitogen-activated protein kinase kinase binding IDA
IDA: Inferred from direct assay
15299019 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25852190 GOA
enables protein kinase inhibitor activity IMP
IMP: Inferred from mutant phenotype
15299019 GOA
Biological Process GO Annotation Evidence References Source
involved in JNK cascade IMP
IMP: Inferred from mutant phenotype
17452330 GOA
involved in negative regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
15299019 GOA
involved in negative regulation of lipopolysaccharide-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
17452330 GOA
involved in negative regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
15299019 GOA
involved in negative regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
17452330 GOA
involved in negative regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17452330 GOA
involved in regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
15299019 GOA
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
17452330 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17452330 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17452330 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIB1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (136 - 338)

  • 0
  • 100
  • 200
  • 300
  • 372 a.a.
Protein Preferred Names Protein Names

tribbles homolog 1

  • G-protein-coupled receptor induced protein

TRIB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRIB1 Q96RU8 STK40 Homo sapiens Q8N2I9
Pull Down
32707033
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypobetalipoproteinemia, Familial, 1

  • Hypobetalipoproteinemia

  • Familial Hypobetalipoproteinemia 1

  • Familial Hypobetalipoproteinemia

  • FHBL1

  • Hypobetalipoproteinemia, Familial

  • Fhbl

  • Acanthocytosis With Hypobetalipoproteinemia

  • Hypobetalipoproteinemias

  • Hypobetalipoproteinemia, Normotriglyceridemic

  • Hypo-Beta-Lipoproteinemia

  • Hypobetalipoprotéinemia, Familial

  • Normotriglyceridemic Hypobetalipoproteinemia

  • Hypobetalipoproteinemia, Familial, Type 1
Hyperlipoproteinemia, Type V

  • Hyperlipoproteinemia Type V

  • Hyperchylomicronemia, Late-Onset

  • Familial Type 5 Hyperlipoproteinemia

  • Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial

  • Hyperlipidemia, Type V

  • Hyperlipemia, Mixed

  • Hyperlipemia, Combined Fat And Carbohydrate-Induced

  • Familial Hyperlipoproteinemia Type V

  • Fredrickson Type V Lipaemia

  • Hyperlipoproteinemia Type 5

  • Hyperchylomicronemia Late Onset

  • Hyperlipemia Combined Fat And Carbohydrate-Induced

  • Hyperlipemia Mixed

  • Hyperlipidemia Type V

  • Mixed Hyperlipemia

  • Type V Hyperlipoproteinemia

  • Hyperlipoproteinemia 5

  • HLPP5

  • Hyperlipidemia, Familial Combined

  • Mixed Hyperlipidemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15015 TRIB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22878 Trib1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29392 Trib1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TRIB1 MGD MGI:2443397
Rattus norvegicus TRIB1 RGD RGD:621596
Bos taurus TRIB1 VGNC VGNC:36308
Macaca mulatta TRIB1 VGNC VGNC:79056
Felis catus TRIB1 VGNC VGNC:66527
Canis familiaris TRIB1 VGNC VGNC:55007
Others TRIB1 NCBI