2. Gene
  3. TRIB1 - tribbles pseudokinase 1 Gene

TRIB1 - tribbles pseudokinase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as C8FW; GIG2; TRB1; GIG-2; SKIP1; TRB-1

Gene ID: 10221 | Gene type: protein coding

About TRIB1

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:125,430,358-125,438,403 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 3 paralogues. Broad expression in bone marrow (RPKM 87.7), liver (RPKM 53.0) and 20 other tissues.

Summary

Enables mitogen-activated protein kinase kinase binding activity and protein kinase inhibitor activity. Involved in several processes, including JNK cascade; negative regulation of lipopolysaccharide-mediated signaling pathway; and regulation of protein kinase activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TRIB1 Products(2)

mRNA Protein Name
NM_001282985.2 NP_001269914.1 tribbles homolog 1 isoform 2
NM_025195.4 NP_079471.1 tribbles homolog 1 isoform 1

TRIB1 Protein Structure

Pkinase

Pkinase: Protein kinase domain (136 - 338)

  • 0
  • 100
  • 200
  • 300
  • 372 a.a.
Protein Preferred Names Protein Names

tribbles homolog 1

G-protein-coupled receptor induced protein

Related Diseases

Diseases Alias
Hypobetalipoproteinemia, Familial, 1

Hypobetalipoproteinemia

Familial Hypobetalipoproteinemia 1

Familial Hypobetalipoproteinemia

FHBL1

Hypobetalipoproteinemia, Familial

Fhbl

Acanthocytosis With Hypobetalipoproteinemia

Hypobetalipoproteinemias

Hypobetalipoproteinemia, Normotriglyceridemic

Hypo-Beta-Lipoproteinemia

Hypobetalipoprotéinemia, Familial

Normotriglyceridemic Hypobetalipoproteinemia

Hypobetalipoproteinemia, Familial, Type 1
Hyperlipoproteinemia, Type V

Hyperlipoproteinemia Type V

Hyperchylomicronemia, Late-Onset

Familial Type 5 Hyperlipoproteinemia

Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial

Hyperlipidemia, Type V

Hyperlipemia, Mixed

Hyperlipemia, Combined Fat And Carbohydrate-Induced

Familial Hyperlipoproteinemia Type V

Fredrickson Type V Lipaemia

Hyperlipoproteinemia Type 5

Hyperchylomicronemia Late Onset

Hyperlipemia Combined Fat And Carbohydrate-Induced

Hyperlipemia Mixed

Hyperlipidemia Type V

Mixed Hyperlipemia

Type V Hyperlipoproteinemia

Hyperlipoproteinemia 5

HLPP5

Hyperlipidemia, Familial Combined

Mixed Hyperlipidemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15015 TRIB1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TRIB1 MGD MGI:2443397
Rattus norvegicus TRIB1 RGD RGD:621596
Bos taurus TRIB1 VGNC VGNC:36308
Macaca mulatta TRIB1 VGNC VGNC:79056
Felis catus TRIB1 VGNC VGNC:66527
Canis familiaris TRIB1 VGNC VGNC:55007