CDK2AP2 - cyclin dependent kinase 2 associated protein 2 Gene

Also Known as p14; DOC1R; DOC-1R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10263

About CDK2AP2

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,506,497-67,508,162 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 21.4), adrenal (RPKM 15.6) and 25 other tissues.

Summary

This gene encodes a protein that interacts with cyclin-dependent kinase 2 associated protein 1. Pseudogenes associated with this gene are located on chromosomes 7 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]

CDK2AP2 Products (2)

mRNA Protein Name
NM_001271849.2 NP_001258778.1 cyclin-dependent kinase 2-associated protein 2 isoform 2
NM_005851.5 NP_005842.1 cyclin-dependent kinase 2-associated protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14985111 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
23781148 GOA
Cellular Component GO Annotation Evidence References Source
part of NuRD complex IDA
IDA: Inferred from direct assay
33283408 GOA
located in nucleus IDA
IDA: Inferred from direct assay
33283408 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK2AP2 Protein Structure

CDK2AP

CDK2AP: Cyclin-dependent kinase 2-associated protein (36 - 126)

  • 0
  • 100
  • 126 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 2-associated protein 2

  • CDK2-associated protein 2

CDK2AP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CDK2AP2 O75956 MRFAP1L1 Homo sapiens Q96HT8
Validated Y2H
32296183
Intra
CDK2AP2 O75956 MRFAP1L1 Homo sapiens Q96HT8
Y2H Array
32296183
Intra
CDK2AP2 O75956 MRFAP1L1 Homo sapiens Q96HT8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDK2AP2 Proteins

Cat. No. Product Name Accession Purity
HY-P7850 CDK2AP2 Protein, Human (HEK293, His) O75956 (M1-T126) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Melnick-Needles Syndrome

  • MNS

  • Melnick-Needles Osteodysplasty

  • Osteodysplasty Of Melnick And Needles

  • Osteochondrodysplasias
Otopalatodigital Syndrome Spectrum Disorder

  • Opd Spectrum Disorder

  • Opsd

  • Fronto-Otopalatodigital Osteodysplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02379 CDK2AP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20627 Cdk2ap2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27136 Cdk2ap2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CDK2AP2 VGNC VGNC:51861
Felis catus CDK2AP2 VGNC VGNC:102755
Macaca mulatta CDK2AP2 VGNC VGNC:107438
Mus musculus CDK2AP2 MGD MGI:1098779
Rattus norvegicus CDK2AP2 RGD RGD:1588883
Bos taurus CDK2AP2 VGNC VGNC:27126
Others CDK2AP2 NCBI