RAMP3 - receptor activity modifying protein 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10268

About RAMP3

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:45,157,791-45,184,250 (from NCBI)

This gene has 3 transcripts (splice variants), 192 orthologues and 2 paralogues. Broad expression in lung (RPKM 28.4), lymph node (RPKM 13.1) and 20 other tissues.

Summary

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (Calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an Adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an Adrenomedullin receptor. [provided by RefSeq, Jul 2008]

RAMP3 Products (1)

mRNA Protein Name
NM_005856.3 NP_005847.1 receptor activity-modifying protein 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables adrenomedullin receptor activity IPI
IPI: Inferred from physical interaction
10882736 GOA
enables amylin receptor activity IGI
IGI: Inferred from genetic interaction
22500019 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15613468 GOA
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
22500019 GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IPI
IPI: Inferred from physical interaction
10882736 GOA
involved in adrenomedullin receptor signaling pathway IPI
IPI: Inferred from physical interaction
10882736 GOA
involved in amylin receptor signaling pathway IGI
IGI: Inferred from genetic interaction
22500019 GOA
involved in calcium ion transport IDA
IDA: Inferred from direct assay
10882736 GOA
involved in cross-receptor inhibition within G protein-coupled receptor heterodimer IPI
IPI: Inferred from physical interaction
14722252 GOA
involved in positive regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
22500019 GOA
involved in positive regulation of cAMP/PKA signal transduction IGI
IGI: Inferred from genetic interaction
22500019 GOA
involved in positive regulation of calcium-mediated signaling IGI
IGI: Inferred from genetic interaction
22500019 GOA
involved in positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
22500019 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
22500019 GOA
involved in positive regulation of protein localization to plasma membrane IDA
IDA: Inferred from direct assay
23674134 GOA
involved in positive regulation of receptor recycling IDA
IDA: Inferred from direct assay
15613468 GOA
involved in protein localization to plasma membrane IDA
IDA: Inferred from direct assay
10882736 GOA
involved in protein transport IDA
IDA: Inferred from direct assay
9620797 GOA
involved in receptor internalization IDA
IDA: Inferred from direct assay
10882736 GOA
involved in response to amyloid-beta IGI
IGI: Inferred from genetic interaction
22500019 GOA
Cellular Component GO Annotation Evidence References Source
part of adrenomedullin receptor complex IDA
IDA: Inferred from direct assay
10882736 GOA
part of amylin receptor complex 3 IDA
IDA: Inferred from direct assay
22500019 GOA
located in cell surface IDA
IDA: Inferred from direct assay
10882736 GOA
colocalizes with lysosome IDA
IDA: Inferred from direct assay
15613468 GOA
colocalizes with plasma membrane IDA
IDA: Inferred from direct assay
9620797 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
15613468 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
15613468 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAMP3 Protein Structure

RAMP

RAMP: Receptor activity modifying family (37 - 146)

  • 0
  • 100
  • 148 a.a.
Protein Preferred Names Protein Names

receptor activity-modifying protein 3

  • CRLR activity-modifying protein 3

RAMP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAMP3 O60896 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra
RAMP3 O60896 KRTAP5-3 Homo sapiens Q6L8H2
Validated Y2H
32296183
Intra
RAMP3 O60896 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra
RAMP3 O60896 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra
RAMP3 O60896 KRTAP5-7 Homo sapiens Q6L8G8
Validated Y2H
32296183
Intra
RAMP3 O60896 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
RAMP3 O60896 NOTCH2NLC Homo sapiens P0DPK4
Validated Y2H
32296183
Intra
RAMP3 O60896 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
RAMP3 O60896 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
RAMP3 O60896 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
RAMP3 O60896 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra
RAMP3 O60896 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra
RAMP3 O60896 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra
RAMP3 O60896 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RAMP3 Proteins

Cat. No. Product Name Accession Purity
HY-P74603 RAMP3 Protein, Human (HEK293, hFc) O60896 (R24-V118) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cartilage Cancer

  • Chondrogenic Neoplasm
Migraine With Or Without Aura 1

  • Migraine

  • Migraine With Or Without Aura, Susceptibility To, 1

  • Migraine Disorder

  • Migraine Variant

  • Migraines

  • Migraine Disorders

  • Mgr1

  • Mgau

  • Ma

  • Migraine With Or Without Aura

  • Classic Migraine

  • Common Migraine

  • Disorder, Migraine

  • Headache Migraine

  • Headache Migrainous

  • Migraine Headache

  • Migraine Syndrome

  • Headache Including Migraine

  • Migraine, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-184982 Estrogen receptor-IN-2 / Unkown
HY-P11584 KBP-066A Agonist / Unkown
HY-RS11640 RAMP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183142 CLR/RAMP3-receptor antagonist-1 Antagonist / Unkown
HY-RS20477 Ramp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26985 Ramp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990497 Anti-RAMP3 Antibody Inhibitor 97.71% Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RAMP3 VGNC VGNC:33708
Canis familiaris RAMP3 VGNC VGNC:54348
Macaca mulatta RAMP3 VGNC VGNC:81750
Mus musculus RAMP3 MGD MGI:1860292
Rattus norvegicus RAMP3 RGD RGD:61873
Felis catus RAMP3 VGNC VGNC:102678
Others RAMP3 NCBI