Fbxw11 - F-box and WD-40 domain protein 11 Gene

Also Known as HOS; BTRC2; BTRCP2; Fbxw1b; 2310065A07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 103583

Summary

Enables ubiquitin-protein transferase activity. Contributes to ubiquitin protein Ligase activity. Involved in several processes, including cellular protein metabolic process; negative regulation of NIK/NF-kappaB signaling; and positive regulation of circadian rhythm. Located in cytosol and nucleus. Part of SCF ubiquitin Ligase complex. Is expressed in cap mesenchyme; early tubule; ovary; and testis. Orthologous to human FBXW11 (F-box and WD repeat domain containing 11). [provided by Alliance of Genome Resources, Apr 2022]

Fbxw11 Products (14)

mRNA Protein Name
NM_001271347.2 NP_001258276.1 F-box/WD repeat-containing protein 11 isoform b
NM_001271348.2 NP_001258277.1 F-box/WD repeat-containing protein 11 isoform c
NM_001271349.2 NP_001258278.1 F-box/WD repeat-containing protein 11 isoform d
NM_001363353.2 NP_001350282.1 F-box/WD repeat-containing protein 11 isoform e
NM_001363354.2 NP_001350283.1 F-box/WD repeat-containing protein 11 isoform f
NM_001363355.2 NP_001350284.1 F-box/WD repeat-containing protein 11 isoform g
NM_134015.4 NP_598776.1 F-box/WD repeat-containing protein 11 isoform a
NM_001271347.2 NP_001258276.1 F-box/WD repeat-containing protein 11 isoform b
NM_001271348.2 NP_001258277.1 F-box/WD repeat-containing protein 11 isoform c
NM_001271349.2 NP_001258278.1 F-box/WD repeat-containing protein 11 isoform d
NM_001363353.2 NP_001350282.1 F-box/WD repeat-containing protein 11 isoform e
NM_001363354.2 NP_001350283.1 F-box/WD repeat-containing protein 11 isoform f
NM_001363355.2 NP_001350284.1 F-box/WD repeat-containing protein 11 isoform g
NM_134015.4 NP_598776.1 F-box/WD repeat-containing protein 11 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11896578 MGI
contributes to ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
11896578 MGI
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
11896578 MGI
Biological Process GO Annotation Evidence References Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
11896578 MGI
involved in negative regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
11896578 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
18782782 MGI
involved in positive regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
18782782 MGI
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
18782782 MGI
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
11896578 MGI
Cellular Component GO Annotation Evidence References Source
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
11896578 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11896578 MGI
located in cytosol IDA
IDA: Inferred from direct assay
18782782 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18782782 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-box/WD repeat-containing protein 11

  • F-box and WD repeats protein beta-TrCP2

  • F-box and WD-40 domain protein 1B

  • F-box/WD repeat-containing protein 1B

  • homologous to Slimb protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04816 FBXW11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21128 Fbxw11 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27646 Fbxw11 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fbxw11 NCBI NCBI:23291